Risk management among benzene-exposed oil refinery workers

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Ten benzene-exposed oil refinery workers were genotoxicologically monitored in an annual follow-up study between 1990 and 2003 and compared with 87 industrial and 26 matched controls. Each of the exposed subjects suffered from several intercurrent non-infectious diseases such as joint, rheumatic, gastric and dental problems, as well as kidney and liver dysfunctions. The structural chromosome aberration (CA) yields of the exposed donors suggested a dose-dependent response to the mean peak benzene concentrations in the ambient air. Sister chromatid exchange (SCE), high-frequency SCE, DNA repair, and cell proliferation data also indicated the presence of genotoxic exposure at the workplace. The results of the biological and genotoxicological monitoring indicated the need of intervention (primary prevention of occupational exposure-related chronic non-infectious diseases) including the introduction of zero tolerance of benzene emission, health control, and education with motivation to change life-styles. The decrease in CA frequencies considered as the most established genotoxicological effect markers indicated the positive changes due to the achieved zero tolerance at the workplaces. The results also demonstrated the effectiveness of a trilateral co-operation between the health services, the employer and the employee in order to reduce the risk of the exposure-related intercurrent non-infectious diseases and to prevent further deterioration of the health state of the workers.

Original languageEnglish
Pages (from-to)509-516
Number of pages8
JournalInternational Journal of Hygiene and Environmental Health
Volume208
Issue number6
DOIs
Publication statusPublished - Nov 18 2005

Fingerprint

Risk Management
Benzene
Oils
Sister Chromatid Exchange
Chromosome Aberrations
Workplace
Occupational Health Services
Environmental Monitoring
Occupational Exposure
Primary Prevention
Health Education
DNA Repair
Life Style
Liver Diseases
Motivation
Stomach
Tooth
Joints
Air
Cell Proliferation

Keywords

  • Benzene
  • Chromosome aberrations
  • Genotoxicological monitoring
  • HPRT mutations
  • Primary prevention
  • Risk assessment
  • Sister chromatid exchange
  • Unscheduled DNA synthesis

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Risk management among benzene-exposed oil refinery workers. / Tompa, A.; Jakab, M.; Major, J.

In: International Journal of Hygiene and Environmental Health, Vol. 208, No. 6, 18.11.2005, p. 509-516.

Research output: Contribution to journalArticle

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