Risk for colorectal cancer in ulcerative colitis

Changes, causes and management strategies

Research output: Contribution to journalArticle

203 Citations (Scopus)

Abstract

The risk of colorectal cancer for any patient with ulcerative colitis is known to be elevated, and is estimated to be 2% after 10 years, 8% after 20 years and 18% after 30 years of disease. Risk factors for cancer include extent and duration of ulcerative colitis, primary sclerosing cholangitis, a family history of sporadic colorectal cancer, severity of histologic bowel inflammation, and in some studies, young age at onset of colitis. In this review, the authors discuss recent epidemiological trends and causes for the observed changes. Population-based studies published within the past 5 years suggest that this risk has decreased over time, despite the low frequency of colectomies. The crude annual incidence rate of colorectal cancer in ulcerative colitis ranges from approximately 0.06% to 0.16% with a relative risk of 1.0-2.75. The exact mechanism for this change is unknown; it may partly be explained by the more widespread use of maintenance therapy and surveillance colonoscopy.

Original languageEnglish
Pages (from-to)3937-3947
Number of pages11
JournalWorld Journal of Gastroenterology
Volume14
Issue number25
DOIs
Publication statusPublished - 2008

Fingerprint

Ulcerative Colitis
Colorectal Neoplasms
Sclerosing Cholangitis
Colectomy
Colitis
Colonoscopy
Age of Onset
Inflammation
Incidence
Population
Neoplasms
Therapeutics

Keywords

  • Chemprevention
  • Colorectal cancer
  • Risk factors
  • Surveillance
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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