Risk factors in the origin of congenital left-ventricular outflow-tract obstruction defects of the heart

A population-based case-control study

Melinda Csáky-Szunyogh, Attila Vereczkey, Zsolt Kósa, Balázs Gerencsér, E. Czeizel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The aim of our project was to study possible etiological factors in the origin of congenital heart defects (CHDs) because in the majority of patients the underlying causes are unclear. Cases with different CHD entities as homogeneously as possible were planned for evaluation in the population-based large data set of the Hungarian Case Control Surveillance of Congenital Abnormalities. Dead or surgically corrected 302 live-born cases with different types of left-ventricular outflow tract obstructive defects (LVOT, i.e., valvular aortic stenosis 76, hypoplastic left heart syndrome 76, coarctation of the aorta 113, and other congenital anomalies of aorta 32) were compared with 469 matched controls, 38,151 controls without any defects, and 20,750 malformed controls with other isolated defects. Medically recorded pregnancy complications and chronic diseases were evaluated based on prenatal maternity logbooks, whereas acute diseases, drug treatments, and folic acid/multivitamin supplementation were analyzed both on the basis of retrospective maternal information and medical records. The results of the study showed the role of maternal diabetes in the origin of LVOT in general, while panic disorder was associated with a higher risk of hypoplastic left heart syndrome and ampicillin treatment with a higher risk of coarctation of the aorta (COA). High doses of folic acid had a protective effect regarding the manifestation of LVOT, particularly COA. In conclusion, only a minor portion of causes was shown in our study; thus, further studies are needed to understand better the underlying causal factors in the origin of LVOT.

Original languageEnglish
Pages (from-to)108-120
Number of pages13
JournalPediatric Cardiology
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 2014

Fingerprint

Ventricular Outflow Obstruction
Aortic Coarctation
Hypoplastic Left Heart Syndrome
Case-Control Studies
Congenital Heart Defects
Folic Acid
Mothers
Population
Pregnancy Complications
Panic Disorder
Aortic Valve Stenosis
Acute Disease
Ampicillin
Medical Records
Aorta
Chronic Disease
Therapeutics
Pharmaceutical Preparations

Keywords

  • Coarctation of the aorta
  • Hypoplastic left heart syndrome
  • Left-ventricular outflow-tract obstructive defects of the heart
  • Maternal diabetes
  • Panic disorder
  • Valvular aortic stenosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Risk factors in the origin of congenital left-ventricular outflow-tract obstruction defects of the heart : A population-based case-control study. / Csáky-Szunyogh, Melinda; Vereczkey, Attila; Kósa, Zsolt; Gerencsér, Balázs; Czeizel, E.

In: Pediatric Cardiology, Vol. 35, No. 1, 01.2014, p. 108-120.

Research output: Contribution to journalArticle

Csáky-Szunyogh, Melinda ; Vereczkey, Attila ; Kósa, Zsolt ; Gerencsér, Balázs ; Czeizel, E. / Risk factors in the origin of congenital left-ventricular outflow-tract obstruction defects of the heart : A population-based case-control study. In: Pediatric Cardiology. 2014 ; Vol. 35, No. 1. pp. 108-120.
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