Ring transformations of 1,3-benzothiazine derivatives II conversion of 6α-aryl-7α-chloro-2,3(2′,3′-dialkqxybenzo)-1-thi aoctems3 into 2-carbomethoxy-3-aryl-7,8-dialkoxy-4.5-dihydro-1,4-benzothiazepines

Lajos Fodor, János Szabó, Erzsébet Szúcs, Gábor Bernáth, Pál Sohár, József Tamás

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23 Citations (Scopus)

Abstract

6,7-Dialkoxy-2-aryl-4H1-1,3-benzothiazines (1a{not implied by}) react with chloroacetyl chlorlde to give condensed β-lactam derivatives (2a{not implied by}). Basic treatment of 2a{not implied by} in methanol led to the corresponding 1,4-banzothiazepine derivativee (3a{not implied by}) viaring expansion. The structures of the products were determined by IR, NMR and MS studies.

Original languageEnglish
Pages (from-to)4089-4095
Number of pages7
JournalTetrahedron
Volume40
Issue number20
DOIs
Publication statusPublished - 1984

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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