Ring transformations of 1,3-benzothiazine derivatives II conversion of 6α-aryl-7α-chloro-2,3(2′,3′-dialkqxybenzo)-1-thi aoctems3 into 2-carbomethoxy-3-aryl-7,8-dialkoxy-4.5-dihydro-1,4-benzothiazepines

L. Fodor, János Szabó, Erzsébet Szúcs, G. Bernáth, P. Sohár, József Tamás

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23 Citations (Scopus)

Abstract

6,7-Dialkoxy-2-aryl-4H1-1,3-benzothiazines (1a{not implied by}) react with chloroacetyl chlorlde to give condensed β-lactam derivatives (2a{not implied by}). Basic treatment of 2a{not implied by} in methanol led to the corresponding 1,4-banzothiazepine derivativee (3a{not implied by}) viaring expansion. The structures of the products were determined by IR, NMR and MS studies.

Original languageEnglish
Pages (from-to)4089-4095
Number of pages7
JournalTetrahedron
Volume40
Issue number20
DOIs
Publication statusPublished - 1984

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Lactams
Methanol
Nuclear magnetic resonance
Derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

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title = "Ring transformations of 1,3-benzothiazine derivatives II conversion of 6α-aryl-7α-chloro-2,3(2′,3′-dialkqxybenzo)-1-thi aoctems3 into 2-carbomethoxy-3-aryl-7,8-dialkoxy-4.5-dihydro-1,4-benzothiazepines",
abstract = "6,7-Dialkoxy-2-aryl-4H1-1,3-benzothiazines (1a{not implied by}) react with chloroacetyl chlorlde to give condensed β-lactam derivatives (2a{not implied by}). Basic treatment of 2a{not implied by} in methanol led to the corresponding 1,4-banzothiazepine derivativee (3a{not implied by}) viaring expansion. The structures of the products were determined by IR, NMR and MS studies.",
author = "L. Fodor and J{\'a}nos Szab{\'o} and Erzs{\'e}bet Sz{\'u}cs and G. Bern{\'a}th and P. Soh{\'a}r and J{\'o}zsef Tam{\'a}s",
year = "1984",
doi = "10.1016/0040-4020(84)85090-5",
language = "English",
volume = "40",
pages = "4089--4095",
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TY - JOUR

T1 - Ring transformations of 1,3-benzothiazine derivatives II conversion of 6α-aryl-7α-chloro-2,3(2′,3′-dialkqxybenzo)-1-thi aoctems3 into 2-carbomethoxy-3-aryl-7,8-dialkoxy-4.5-dihydro-1,4-benzothiazepines

AU - Fodor, L.

AU - Szabó, János

AU - Szúcs, Erzsébet

AU - Bernáth, G.

AU - Sohár, P.

AU - Tamás, József

PY - 1984

Y1 - 1984

N2 - 6,7-Dialkoxy-2-aryl-4H1-1,3-benzothiazines (1a{not implied by}) react with chloroacetyl chlorlde to give condensed β-lactam derivatives (2a{not implied by}). Basic treatment of 2a{not implied by} in methanol led to the corresponding 1,4-banzothiazepine derivativee (3a{not implied by}) viaring expansion. The structures of the products were determined by IR, NMR and MS studies.

AB - 6,7-Dialkoxy-2-aryl-4H1-1,3-benzothiazines (1a{not implied by}) react with chloroacetyl chlorlde to give condensed β-lactam derivatives (2a{not implied by}). Basic treatment of 2a{not implied by} in methanol led to the corresponding 1,4-banzothiazepine derivativee (3a{not implied by}) viaring expansion. The structures of the products were determined by IR, NMR and MS studies.

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M3 - Article

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EP - 4095

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

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