N-Methyl-, N-ethyl-, N-(n-propyl)-, N-(iso-propyl)- and N-phenyl-2- arylimidazolidines proved to be ring-chain tautomeric mixtures in CDCl3. The ratios of the open and ring forms in the tautomeric equilibria of these compounds is described by the equation log K(x) = pσ+ + log K(x)-(II), used earlier for the ring-chain equilibria of saturated 2-aryl-1,3-O,N- heterocycles. These are the first examples among 2-arylimidazolidines of ring-chain tautomeric processes characterized by a Hammett-type correlation.
- Electronic and steric effects
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry