Rigid cinchona conformers in enantioselective catalytic reactions: New cinchona-modified platinum catalysts in the Orito reaction

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52 Citations (Scopus)

Abstract

The use of cinchona alkaloids (cinchonidine, cinchonine, quinine, quinidine, α-isocinchonine, α-isoquinidine, γ-isoquinidine) in the Orito reaction (hydrogenation of ethyl pyruvate and ethyl benzoylformate) strongly supports the structure of the intermediate complex (cinchona alkaloid "anti-open" conformer-pyruvate 1:1 complex); in addition, so far unknown stereochemical conditions have been identified and the utilization of rigid cinchona conformers in the study of asymmetric syntheses have been generalized.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalCatalysis Letters
Volume61
Issue number1-2
Publication statusPublished - Aug 1 1999

Keywords

  • Chiral
  • Cinchona alkaloids
  • Ethyl benzoylformate
  • Ethyl pyruvate
  • Hydrogenation
  • Rigid conformers

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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