Right ventricular adaptation is associated with the Glu298Asp variant of the NOS3 gene in elite athletes

Zsolt Szelid, Árpád Lux, Márton Kolossváry, Attila Tóth, Hajnalka Vágó, Zsuzsanna Lendvai, Loretta Kiss, Pál Maurovich-Horvat, Zsolt Bagyura, B. Merkely

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Nitric oxide (NO), an important endogenous pulmonary vasodilator is synthetized by the endothelial NO synthase (NOS3). Reduced NO bioavailability and thus the Glu298Asp polymorphism of NOS3 may enhance right ventricular (RV) afterload and hypertrophic remodeling and influence athletic performance. To test this hypothesis world class level athletes (water polo players, kayakers, canoeists, rowers, swimmers, n = 126) with a VO2 maximum greater than 50ml/kg/min were compared with non-athletic volunteers (n = 155). Cardiopulmonary exercise tests and cardiac magnetic resonance imaging (cMRI) were performed to determine structural or functional changes. Genotype distribution of the NOS3 Glu298Asp polymorphism was not affected by gender or physical performance. Cardiac MRI showed increased stroke volume with eccentric hypertrophy in all athletes regardless of their genotype. However, the Asp allelic variant carriers had increased RV mass index (32±6g versus 27±6g, p

Original languageEnglish
Article numbere0141680
JournalPLoS One
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 30 2015

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athletes
Polymorphism
Athletes
Nitric Oxide
Genes
Genotype
Athletic Performance
Nitric Oxide Synthase Type III
Magnetic resonance
Viperidae
Water levels
Vasodilator Agents
Exercise Test
Stroke Volume
Magnetic resonance imaging
Hypertrophy
Biological Availability
nitric oxide
Volunteers
genes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Right ventricular adaptation is associated with the Glu298Asp variant of the NOS3 gene in elite athletes. / Szelid, Zsolt; Lux, Árpád; Kolossváry, Márton; Tóth, Attila; Vágó, Hajnalka; Lendvai, Zsuzsanna; Kiss, Loretta; Maurovich-Horvat, Pál; Bagyura, Zsolt; Merkely, B.

In: PLoS One, Vol. 10, No. 10, e0141680, 30.10.2015.

Research output: Contribution to journalArticle

Szelid, Z, Lux, Á, Kolossváry, M, Tóth, A, Vágó, H, Lendvai, Z, Kiss, L, Maurovich-Horvat, P, Bagyura, Z & Merkely, B 2015, 'Right ventricular adaptation is associated with the Glu298Asp variant of the NOS3 gene in elite athletes', PLoS One, vol. 10, no. 10, e0141680. https://doi.org/10.1371/journal.pone.0141680
Szelid, Zsolt ; Lux, Árpád ; Kolossváry, Márton ; Tóth, Attila ; Vágó, Hajnalka ; Lendvai, Zsuzsanna ; Kiss, Loretta ; Maurovich-Horvat, Pál ; Bagyura, Zsolt ; Merkely, B. / Right ventricular adaptation is associated with the Glu298Asp variant of the NOS3 gene in elite athletes. In: PLoS One. 2015 ; Vol. 10, No. 10.
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