Rhinophototherapy in persistent allergic rhinitis

Zsolt Bella, Ágnes Kiricsi, Éva Dósa Rácz Viharosné, Attila Dallos, Ádám Perényi, M. Kiss, Andrea Koreck, L. Kemény, József Jóri, László Rovó, Edit Kadocsa

Research output: Contribution to journalArticle

1 Citation (Scopus)


Previous published results have revealed that Rhinolight® intranasal phototherapy is safe and effective in intermittent allergic rhinitis. The present objective was to assess whether phototherapy is also safe and effective in persistent allergic rhinitis. Thirty-four patients with persistent allergic rhinitis were randomized into two groups; twenty-five subjects completed the study. The Rhinolight® group was treated with a combination of UV-B, UV-A, and high-intensity visible light, while the placebo group received low-intensity visible white light intranasal phototherapy on a total of 13 occasions in 6 weeks. The assessment was based on the diary of symptoms, nasal inspiratory peak flow, quantitative smell threshold, mucociliary transport function, and ICAM-1 expression of the epithelial cells. All nasal symptom scores and nasal inspiratory peak flow measurements improved significantly in the Rhinolight® group relative to the placebo group and this finding persisted after 4 weeks of follow-up. The smell and mucociliary functions did not change significantly in either group. The number of ICAM-1 positive cells decreased non-significantly in the Rhinolight® group. No severe side-effects were reported during the treatment period. These results suggest that Rhinolight® treatment is safe and effective in persistent allergic rhinitis.

Original languageEnglish
Pages (from-to)1543-1550
Number of pages8
JournalEuropean Archives of Oto-Rhino-Laryngology
Issue number3
Publication statusPublished - Mar 1 2017



  • Intercellular adhesion molecule-1 expression
  • Intranasal phototherapy
  • Mucociliary clearance
  • Nasal inspiratory peak flow
  • Persistent allergic rhinitis
  • Rhinolight

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Bella, Z., Kiricsi, Á., Viharosné, É. D. R., Dallos, A., Perényi, Á., Kiss, M., Koreck, A., Kemény, L., Jóri, J., Rovó, L., & Kadocsa, E. (2017). Rhinophototherapy in persistent allergic rhinitis. European Archives of Oto-Rhino-Laryngology, 274(3), 1543-1550. https://doi.org/10.1007/s00405-016-4358-x