Rhinophototherapy: A new therapeutic tool for the management of allergic rhinitis

Andrea I. Koreck, Zsanett Csoma, Laszlo Bodai, Ferenc Ignacz, Anna Szabo Kenderessy, Edit Kadocsa, Gabor Szabo, Zsolt Bor, Anna Erdei, Barnabas Szony, Bernhard Homey, Attila Dobozy, Lajos Kemeny

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50 Citations (Scopus)


Background: Phototherapy has a profound immunosuppressive effect and is able to inhibit hypersensibility reactions in the skin. Objective: We evaluated whether phototherapy using a combination of UV-B (5%), UV-A (25%), and visible light (70%), referred to as mUV/VIS, is effective in treating allergic rhinitis. Methods: We conducted a randomized, double-blind study, in 49 patients with hay fever. The study was performed during the ragweed season. Each intranasal cavity was illuminated 3 times a week for 3 weeks with mUV/VIS or with low-intensity visible light. Symptom scores, inflammatory cells, and their mediators were assessed in nasal lavages. In vitro effects of mUV/VIS irradiation on T-cell and eosinophil apoptosis and its inhibitory effect on mediator release from basophils were examined. Results: Rhinophototherapy was tolerated well and resulted in a significant improvement of clinical symptoms for sneezing (P <. 016), rhinorrhea (P <. 007), nasal itching (P <. 014), and total nasal score (P <. 004). None of the scores improved significantly in the control group. Scores for nasal obstruction slightly improved after mUV/VIS treatment and significantly increased in the control group (P <. 017). In the nasal lavage, phototherapy significantly reduced the number of eosinophils and the level of eosinophil cationic protein and IL-5. In vitro irradiation of T cells and eosinophils with mUV/VIS light dose-dependently induced apoptosis. Furthermore, mUV/VIS irradiation inhibited the mediator release from RBL-2H3 basophils. Conclusion: These results suggest that phototherapy is an effective modality to treat allergic rhinitis and offer new options for the treatment of immune-mediated mucosal diseases.

Original languageEnglish
Pages (from-to)541-547
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Issue number3
Publication statusPublished - Mar 2005


  • Allergic rhinitis
  • Apoptosis
  • Eosinophils
  • IL-5
  • Phototherapy
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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