Rheumatoid factors bind β2 microglobulin. Detection of β2 microglobulin-complexes in rheumatoid arthritis

A. Falus, K. Meretey, U. Boehm, S. Bozsoky

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Abstract

β2 microglobulin binding rheumatoid factors and occurrence of complexed form of β2 microglobulin were found in rheumatoid arthritis (RA) by radioimmunological methods. As related to the appropriate values of control sera and osteoarthritic synovial fluids, one of the six sera and five of the six synovial fluids of RA patients exhibited increased binding activity for 125I-β2 microglobulin. Rheumatoid factors (RF) purified by means of immunoadsorbent bound β2 microglobulin. Both 19S and 7S components of sera, synovial fluids and purified RF samples had β2 microglobulin binding activity, which was inhibited by an excess of unlabeled β2-microglobulin. Complexed (3% PEG 6000 insoluble) β2 microglobulin was found in three of fourteen sera and in twelve of fourteen synovial fluids of RA patients. Level of complexed β2 microglobulin was independent of its total concentration in the original samples. In the fraction of synovial fluids enriched immune complex, the amount of β2 microglobulin was in positive correlation with quantity of RF. Presumable immunological and pathological significance of 'anti-β2 microglobulin'-like cross-reactive RF antibodies is discussed.

Original languageEnglish
Pages (from-to)647-654
Number of pages8
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume27
Issue number5
Publication statusPublished - 1979

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Rheumatoid Factor
Synovial Fluid
Rheumatoid Arthritis
Serum
Immunosorbents
Antigen-Antibody Complex
Antibodies

ASJC Scopus subject areas

  • Immunology

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Rheumatoid factors bind β2 microglobulin. Detection of β2 microglobulin-complexes in rheumatoid arthritis. / Falus, A.; Meretey, K.; Boehm, U.; Bozsoky, S.

In: Archivum Immunologiae et Therapiae Experimentalis, Vol. 27, No. 5, 1979, p. 647-654.

Research output: Contribution to journalArticle

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