Rheumatoid arthritis diagnosis with antimutated citrullinated vimentin ELISA by Orgentec Diagnostika

Zoltán Szekanecz, Gabriella Lakos

Research output: Contribution to journalReview article

2 Citations (Scopus)


Background: There is a need for highly sensitive and specific laboratory tests for the early diagnosis of rheumatoid arthritis (RA). Anticitrullinated protein/peptide antibodies are produced in the sera of RA patients. Objective: To assess and discuss the diagnostic value of Orgentec antimutated citrullinated vimentin (anti-MCV) ELISA and to compare this diagnostic to commercially available anticyclic citrullinated peptide (anti-CCP) tests. Methods: The evaluation is based on our recently published study on the comparison of anti-MCV and anti-CCP2 tests, as well as on published studies. Results/conclusion: In established RA, the anti-MCV ELISA exerts a specificity comparable with anti-CCP2. Numerous recent studies suggest that anti-MCV may have higher sensitivity, however there are also some publications stating the opposite. In early RA, anti-MCV may be a better predictor of disease activity and radiological progression than anti-CCP tests.

Original languageEnglish
Pages (from-to)1083-1090
Number of pages8
JournalExpert Opinion on Medical Diagnostics
Issue number9
Publication statusPublished - Sep 1 2008


  • Anticyclic citrullinated peptide
  • Antimutated citrullinated vimentin
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Medicine
  • Biochemistry, medical

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