Rheumatoid arthritis (RA) is histologically characterized by chronic inflammatory sinovitis and pronounced activation of local angiogenesis in the involved joints. Hypoxia of inflammatory cells and their environment is thought to be responsible for the enhanced angiogenesis. Pharmacological inhibition of angiogenesis may have a role in the modern treatment of rheumatoid arthritis, therefore, in this article the authors give a detailed description of the the RA-specific aspects of the regulation of angiogenesis. In this context, the new and innovative treatments of rheumatoid arthritis that may involve modulation of angiogenesis, are introduced.
|Number of pages||8|
|Publication status||Published - Dec 1 2003|
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