Polimer gyógyszerhordozó rendszerek reológiai és biofarmáciai vizsgálata

Translated title of the contribution: Rheological and biopharmaceutical investigation of polymer drug delivery systems

I. Erös, Anita Blum, Erzsébet Csányi, Ildikó Csóka, Ferenc Illyés, Tünde Takács-Wormsdorff

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Drug release of watersoluble active agent (ephedrine hydrochloride) and water-insoluble ones (griseofulvine, salicylic acid, sulfadimidine) from hydrogels containing different polymers was investigated. The rheological behaviour of polymer matrices was characterized by flow curves and viscosity curves. These hydrogels were not thixotropic systems, unlike more authors' statement. The values of rheological constants increase exponetially with concentration of polimers. The liberation of active agents can be characterized by a multiplicative function. The constant of viscosity vs. concentration function was determined and it was called as characteristic of structure formation. A linear relationship between constant of structure formation and drug liberation was demonstrated.

Original languageHungarian
Pages (from-to)139-145
Number of pages7
JournalActa Pharmaceutica Hungarica
Volume73
Issue number3
Publication statusPublished - 2003

Fingerprint

Hydrogels
Drug Delivery Systems
Viscosity
Polymers
Sulfamethazine
Ephedrine
Salicylic Acid
Water
Drug Liberation

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Erös, I., Blum, A., Csányi, E., Csóka, I., Illyés, F., & Takács-Wormsdorff, T. (2003). Polimer gyógyszerhordozó rendszerek reológiai és biofarmáciai vizsgálata. Acta Pharmaceutica Hungarica, 73(3), 139-145.

Polimer gyógyszerhordozó rendszerek reológiai és biofarmáciai vizsgálata. / Erös, I.; Blum, Anita; Csányi, Erzsébet; Csóka, Ildikó; Illyés, Ferenc; Takács-Wormsdorff, Tünde.

In: Acta Pharmaceutica Hungarica, Vol. 73, No. 3, 2003, p. 139-145.

Research output: Contribution to journalArticle

Erös, I, Blum, A, Csányi, E, Csóka, I, Illyés, F & Takács-Wormsdorff, T 2003, 'Polimer gyógyszerhordozó rendszerek reológiai és biofarmáciai vizsgálata', Acta Pharmaceutica Hungarica, vol. 73, no. 3, pp. 139-145.
Erös I, Blum A, Csányi E, Csóka I, Illyés F, Takács-Wormsdorff T. Polimer gyógyszerhordozó rendszerek reológiai és biofarmáciai vizsgálata. Acta Pharmaceutica Hungarica. 2003;73(3):139-145.
Erös, I. ; Blum, Anita ; Csányi, Erzsébet ; Csóka, Ildikó ; Illyés, Ferenc ; Takács-Wormsdorff, Tünde. / Polimer gyógyszerhordozó rendszerek reológiai és biofarmáciai vizsgálata. In: Acta Pharmaceutica Hungarica. 2003 ; Vol. 73, No. 3. pp. 139-145.
@article{e63969455e9a477e9da1e8cc985fa10a,
title = "Polimer gy{\'o}gyszerhordoz{\'o} rendszerek reol{\'o}giai {\'e}s biofarm{\'a}ciai vizsg{\'a}lata",
abstract = "Drug release of watersoluble active agent (ephedrine hydrochloride) and water-insoluble ones (griseofulvine, salicylic acid, sulfadimidine) from hydrogels containing different polymers was investigated. The rheological behaviour of polymer matrices was characterized by flow curves and viscosity curves. These hydrogels were not thixotropic systems, unlike more authors' statement. The values of rheological constants increase exponetially with concentration of polimers. The liberation of active agents can be characterized by a multiplicative function. The constant of viscosity vs. concentration function was determined and it was called as characteristic of structure formation. A linear relationship between constant of structure formation and drug liberation was demonstrated.",
author = "I. Er{\"o}s and Anita Blum and Erzs{\'e}bet Cs{\'a}nyi and Ildik{\'o} Cs{\'o}ka and Ferenc Illy{\'e}s and T{\"u}nde Tak{\'a}cs-Wormsdorff",
year = "2003",
language = "Hungarian",
volume = "73",
pages = "139--145",
journal = "Acta Pharmaceutica Hungarica",
issn = "0001-6659",
publisher = "Magyar Gyogyszereszeti Tarsasag",
number = "3",

}

TY - JOUR

T1 - Polimer gyógyszerhordozó rendszerek reológiai és biofarmáciai vizsgálata

AU - Erös, I.

AU - Blum, Anita

AU - Csányi, Erzsébet

AU - Csóka, Ildikó

AU - Illyés, Ferenc

AU - Takács-Wormsdorff, Tünde

PY - 2003

Y1 - 2003

N2 - Drug release of watersoluble active agent (ephedrine hydrochloride) and water-insoluble ones (griseofulvine, salicylic acid, sulfadimidine) from hydrogels containing different polymers was investigated. The rheological behaviour of polymer matrices was characterized by flow curves and viscosity curves. These hydrogels were not thixotropic systems, unlike more authors' statement. The values of rheological constants increase exponetially with concentration of polimers. The liberation of active agents can be characterized by a multiplicative function. The constant of viscosity vs. concentration function was determined and it was called as characteristic of structure formation. A linear relationship between constant of structure formation and drug liberation was demonstrated.

AB - Drug release of watersoluble active agent (ephedrine hydrochloride) and water-insoluble ones (griseofulvine, salicylic acid, sulfadimidine) from hydrogels containing different polymers was investigated. The rheological behaviour of polymer matrices was characterized by flow curves and viscosity curves. These hydrogels were not thixotropic systems, unlike more authors' statement. The values of rheological constants increase exponetially with concentration of polimers. The liberation of active agents can be characterized by a multiplicative function. The constant of viscosity vs. concentration function was determined and it was called as characteristic of structure formation. A linear relationship between constant of structure formation and drug liberation was demonstrated.

UR - http://www.scopus.com/inward/record.url?scp=0142027329&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142027329&partnerID=8YFLogxK

M3 - Article

VL - 73

SP - 139

EP - 145

JO - Acta Pharmaceutica Hungarica

JF - Acta Pharmaceutica Hungarica

SN - 0001-6659

IS - 3

ER -