Polimer gyógyszerhordozó rendszerek reológiai és biofarmáciai vizsgálata

Translated title of the contribution: Rheological and biopharmaceutical investigation of polymer drug delivery systems

István Eros, Anita Blum, Erzsébet Csányi, Ildikó Csóka, Ferenc Illyés, Tünde Takács-Wormsdorff

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Drug release of watersoluble active agent (ephedrine hydrochloride) and water-insoluble ones (griseofulvine, salicylic acid, sulfadimidine) from hydrogels containing different polymers was investigated. The rheological behaviour of polymer matrices was characterized by flow curves and viscosity curves. These hydrogels were not thixotropic systems, unlike more authors' statement. The values of rheological constants increase exponetially with concentration of polimers. The liberation of active agents can be characterized by a multiplicative function. The constant of viscosity vs. concentration function was determined and it was called as characteristic of structure formation. A linear relationship between constant of structure formation and drug liberation was demonstrated.

Original languageHungarian
Pages (from-to)139-145
Number of pages7
JournalActa pharmaceutica Hungarica
Volume73
Issue number3
Publication statusPublished - Oct 30 2003

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ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Eros, I., Blum, A., Csányi, E., Csóka, I., Illyés, F., & Takács-Wormsdorff, T. (2003). Polimer gyógyszerhordozó rendszerek reológiai és biofarmáciai vizsgálata. Acta pharmaceutica Hungarica, 73(3), 139-145.