Revisiting ubiquity and tissue specificity of human calpains

Attila Farkas, Peter Tompa, Peter Friedrich

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The abundance of mRNAs transcribed from human genes of the calpain superfamily was studied in 72 human tissues and cell types by the Human Multiple Tissue Expression (MTE™) Array technique. The analysis included the large subunits of μ- and m-calpains, the small subunits, calpastatin and calpain 3 (p94). Besides specific data on transcriptional activity, two major conclusions emerged: (i) 'ubiquitous' calpains are not expressed in all cell types, and (ii) a 'tissue-specific' calpain may be expressed in many cell types apart from the one in which it is particularly abundant. Therefore, the categoric classification of 'ubiquitous' vs. 'tissue-specific' calpains is a simplification.

Original languageEnglish
Pages (from-to)945-949
Number of pages5
JournalBiological Chemistry
Volume384
Issue number6
DOIs
Publication statusPublished - Jun 1 2003

Keywords

  • Calpain expression/MTE™
  • Tissue-specific calpain
  • Ubiquitous calpain

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry

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