A retinoidok onkogenetikai hatasai

Translated title of the contribution: Review on the genetical effects of retinoids

A. Tokes, M. Fuzesi, I. Ember

Research output: Contribution to journalReview article

Abstract

Retinoids, that are the biologically active metabolits of vitamin A, may affect the growth and differentiation of normal and transformed cells. They play a part especially in the differentiation of the epidermal cells and at the same time may develop carcinogenic potential as well. Their effect is performed through retinoic acid nuclear receptors (RARα, β, γ and RXRα, β, γ) and cytoplasmic retinoic acid binding proteins (CRBP and CRABP). The nuclear receptors play an important role in the regulation of gene transcription in a ligand-dependent manner binding to specific DNA-sites. By affecting the expression of different (onco)genes nuclear receptors play a role in the regulation of the cell-cycle defining the potential for proliferation and differentiation of the tumor cells. Therefore we reviewed the effects of retinoids on oncogenes and the eventual possibilities for prevention and therapy.

Original languageHungarian
Pages (from-to)508-515
Number of pages8
JournalLege Artis Medicinae
Volume6
Issue number9-10
Publication statusPublished - Dec 1 1996

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tokes, A., Fuzesi, M., & Ember, I. (1996). A retinoidok onkogenetikai hatasai. Lege Artis Medicinae, 6(9-10), 508-515.