Retinoids, that are the biologically active metabolits of vitamin A, may affect the growth and differentiation of normal and transformed cells. They play a part especially in the differentiation of the epidermal cells and at the same time may develop carcinogenic potential as well. Their effect is performed through retinoic acid nuclear receptors (RARα, β, γ and RXRα, β, γ) and cytoplasmic retinoic acid binding proteins (CRBP and CRABP). The nuclear receptors play an important role in the regulation of gene transcription in a ligand-dependent manner binding to specific DNA-sites. By affecting the expression of different (onco)genes nuclear receptors play a role in the regulation of the cell-cycle defining the potential for proliferation and differentiation of the tumor cells. Therefore we reviewed the effects of retinoids on oncogenes and the eventual possibilities for prevention and therapy.
|Number of pages||8|
|Journal||Lege Artis Medicinae|
|Publication status||Published - Dec 1 1996|
ASJC Scopus subject areas