Bioanalitikai modszerek osszehasonlitasa es kovetelmeny rendszerenek bemutatasa a farmakokinetikai gyakorlatban

Translated title of the contribution: Review on bioanalytical methods in pharmacokinetic practice

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The analytical methods used in pharmacokinetic practice are reviewed. The system of special pharmacokinetic demands on bioanalytical methods for carrying out the different pharmacokinetic, metabolite kinetic, bioequivalence and food interaction studies is demonstrated in details (high sensitivity; the parallel measurability of the parent compound and its metabolites; species and biological matrices dependent methods; anticoagulation; sample preparation; derivatisation; special calibration system; method selectivity; reproducibility; validation; economicalness). The different immunological methods and separation techniques used in pharmacokinetic practice and the sensitivity of the detectors have been compared and characterized. Without the requirement of completeness, the author has tried to summarize the most important bioanalytical techniques in the view of general and specific feature; the possibilities of application, characteristics of operation and limitations.

Translated title of the contributionReview on bioanalytical methods in pharmacokinetic practice
Original languageHungarian
Pages (from-to)234-248
Number of pages15
JournalActa pharmaceutica Hungarica
Volume68
Issue number4
Publication statusPublished - Jul 1 1998

ASJC Scopus subject areas

  • Pharmaceutical Science

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