Review of the potential photo-cocarcinogenicity of topical calcineurin inhibitors: Position statement of the European Dermatology Forum

J. Ring, J. Barker, H. Behrendt, L. Braathen, U. Darsow, L. Dubertret, A. Giannetti, J. Hawk, H. Hönigsmann, L. Kemeny, T. Luger, M. Meurer, G. Murphy, A. Peserico, A. Ranki, T. Reunala, J. Saurat, W. Sterry, P. Van De Kerkhof

Research output: Contribution to journalReview article

71 Citations (Scopus)

Abstract

Topical Calcineurin Inhibitors (TCIs) used for the treatment of atopic eczema modify the immune regulatory function of the skin and may have the potential to enhance immunosuppressive ultraviolet (UV) effects. Current recommendations on UV protection in eczema patients treated with PCIs are inconsistent and have given rise to uncertainty and anxiety in patients. Therefore, the European Dermatology Forum (EDF) developed a position statement which reviews critically the available data with regard to the problem, especially analysing and commenting the limitations of rodent models for the human situation. There is no conclusive evidence from rodent trials to indicate that long-term application of TCIs is photococarcinogenic. There is a need for further studies to investigate the validity of mouse models as well as long-term cohort studies in patients using TCIs. Available data suggest that long-term application of TCIs is safe, that there is no evidence of increased skin cancer risk and that it is ethical to treat patients with TCIs when indicated.

Original languageEnglish
Pages (from-to)663-671
Number of pages9
JournalJournal of the European Academy of Dermatology and Venereology
Volume19
Issue number6
DOIs
Publication statusPublished - Nov 1 2005

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Keywords

  • Atopic eczema
  • Carcinogenicity
  • Immunosuppression
  • Photocarcinogenicity
  • Rodent models
  • Topical calcineurin inhibitors

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

Ring, J., Barker, J., Behrendt, H., Braathen, L., Darsow, U., Dubertret, L., Giannetti, A., Hawk, J., Hönigsmann, H., Kemeny, L., Luger, T., Meurer, M., Murphy, G., Peserico, A., Ranki, A., Reunala, T., Saurat, J., Sterry, W., & Van De Kerkhof, P. (2005). Review of the potential photo-cocarcinogenicity of topical calcineurin inhibitors: Position statement of the European Dermatology Forum. Journal of the European Academy of Dermatology and Venereology, 19(6), 663-671. https://doi.org/10.1111/j.1468-3083.2005.01315.x