Review of somatic cell nuclear transfer in pig

Suchitra Muenthaisong, A. Dinnyés, Tshimangadzo Lucky Nedambale

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

It is now more than 8 years, since the first cloned pig from nuclear transfer was reported. Success of somatic cell nuclear transfer (SCNT) in pig is still low compared to that in bovine. Embryonic and neonatal abnormalities of cloned piglets are probably a result of incorrect or incomplete reprogramming of the transferred donor cell nuclei. Recently, technical refinements have resulted in a considerable increase of SCNT efficiency. The current level of efficiency is already sufficient for special purposes with high scientific and commercial impact including xenotransplantation, generation of human disease models and for biomedical studies. In this paper, we review current pig cloning methodologies for the technical and potential applications.

Original languageEnglish
Pages (from-to)17384-17390
Number of pages7
JournalAfrican Journal of Biotechnology
Volume10
Issue number76
DOIs
Publication statusPublished - Nov 30 2011

Fingerprint

somatic cells
Swine
swine
xenotransplantation
Heterologous Transplantation
disease models
cell nucleus
Cell Nucleus
human diseases
piglets
Organism Cloning
molecular cloning
cattle
methodology

Keywords

  • Nuclear transfer
  • Oocyte and embryo
  • Pig
  • Somatic cell

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Genetics
  • Molecular Biology
  • Agronomy and Crop Science

Cite this

Review of somatic cell nuclear transfer in pig. / Muenthaisong, Suchitra; Dinnyés, A.; Nedambale, Tshimangadzo Lucky.

In: African Journal of Biotechnology, Vol. 10, No. 76, 30.11.2011, p. 17384-17390.

Research output: Contribution to journalArticle

Muenthaisong, Suchitra ; Dinnyés, A. ; Nedambale, Tshimangadzo Lucky. / Review of somatic cell nuclear transfer in pig. In: African Journal of Biotechnology. 2011 ; Vol. 10, No. 76. pp. 17384-17390.
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