Review of radiosurgery of pineal parenchymal tumors. Long survival following 125-iodine brachytherapy of pineoblastomas in 2 cases

Jenö Julow, Á Viola, T. Major

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: The aim of the present work is to report the volumetric changes of tumor in two pineoblastoma patients treated with stereotactic interstitial irradiation and to present a review on radiosurgery of pineal parenchymal tumors. Methods: Two of our patients with pineoblastoma were treated with CT and image-fusion guided 125-iodine brachytherapy. The tumor volumes were determined with outlined contours on planning and control CT/MRI images and were compared. Results: Until January 2006, there were 61- and 58-month follow-up periods in the two cases. 56 and 53 months after irradiation the MRI images showed significant tumor shrinkage. In case 1 tumor volume was 0.76 cm3 on the last control MRI image, compared to the 2.87 cm3 at the time of interstitial irradiation, which means 73% shrinkage. In case 2, tumor volume measured with the last control MRI examination was 0.29 cm3, which represents 77% shrinkage of the original tumor volume. In both Cases 1 and 2, PET examinations using 11C-methionine showed no active tumor mass 56 and 53 months following brachytherapy. Conclusion: Two successful treatments of pineoblastoma are reported. The interstitial irradiation of the tumors decreased their volumes significantly. The CT and image fusion-guided 125-iodine stereotactic brachytherapy can be planned well dosimetrically and is surgically precise.

Original languageEnglish
Pages (from-to)276-281
Number of pages6
JournalMinimally Invasive Neurosurgery
Volume49
Issue number5
DOIs
Publication statusPublished - Oct 2006

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Pinealoma
Radiosurgery
Brachytherapy
Tumor Burden
Iodine
Survival
Neoplasms
Methionine

Keywords

  • 125-iodine interstitial irradiation
  • Brachytherapy
  • Image fusion
  • Pineoblastoma
  • Shrinkage

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Review of radiosurgery of pineal parenchymal tumors. Long survival following 125-iodine brachytherapy of pineoblastomas in 2 cases. / Julow, Jenö; Viola, Á; Major, T.

In: Minimally Invasive Neurosurgery, Vol. 49, No. 5, 10.2006, p. 276-281.

Research output: Contribution to journalArticle

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