Review of global rotavirus strain prevalence data from six years post vaccine licensure surveillance: Is there evidence of strain selection from vaccine pressure?

Renáta Dóró, Brigitta László, Vito Martella, Eyal Leshem, Jon Gentsch, Umesh Parashar, K. Bányai

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Comprehensive reviews of pre licensure rotavirus strain prevalence data indicated the global importance of six rotavirus genotypes, G1P[8], G2P[4], G3P[8], G4P[8], G9P[8] and G12P[8]. Since 2006, two vaccines, the monovalent Rotarix (RV1) and the pentavalent RotaTeq (RV5) have been available in over 100 countries worldwide. Of these, 60 countries have already introduced either RV1 or RV5 in their national immunization programs. Post licensure vaccine effectiveness is closely monitored worldwide. This review aimed at describing the global changes in rotavirus strain prevalence over time. The genotype distribution of the nearly 47,000 strains that were characterized during 2007-2012 showed similar picture to that seen in the preceding period. An intriguing finding was the transient predominance of heterotypic strains, mainly in countries using RV1. Unusual and novel antigen combinations continue to emerge, including some causing local outbreaks, even in vaccinated populations. In addition, vaccine strains have been found in both vaccinated infants and their contacts and there is evidence for genetic interaction between vaccine and wild-type strains. In conclusion, the post-vaccine introduction strain prevalence data do not show any consistent pattern indicative of selection pressure resulting from vaccine use, although the increased detection rate of heterotypic G2P[4] strains in some countries following RV1 vaccination is unusual and this issue requires further monitoring.

Original languageEnglish
Pages (from-to)446-461
Number of pages16
JournalInfection, Genetics and Evolution
Volume28
DOIs
Publication statusPublished - Dec 1 2014

Fingerprint

Rotavirus
vaccine
Licensure
Vaccines
vaccines
Pressure
monitoring
genotype
Genotype
Immunization Programs
immunization
vaccination
antigen
global change
Disease Outbreaks
surveillance
Vaccination
Antigens
antigens
Population

Keywords

  • Genotype
  • Rotarix
  • RotaTeq
  • Rotavirus
  • Surveillance

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Molecular Biology
  • Microbiology
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Review of global rotavirus strain prevalence data from six years post vaccine licensure surveillance : Is there evidence of strain selection from vaccine pressure? / Dóró, Renáta; László, Brigitta; Martella, Vito; Leshem, Eyal; Gentsch, Jon; Parashar, Umesh; Bányai, K.

In: Infection, Genetics and Evolution, Vol. 28, 01.12.2014, p. 446-461.

Research output: Contribution to journalArticle

Dóró, Renáta ; László, Brigitta ; Martella, Vito ; Leshem, Eyal ; Gentsch, Jon ; Parashar, Umesh ; Bányai, K. / Review of global rotavirus strain prevalence data from six years post vaccine licensure surveillance : Is there evidence of strain selection from vaccine pressure?. In: Infection, Genetics and Evolution. 2014 ; Vol. 28. pp. 446-461.
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