Reversion of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone a non-covalently binding ligand of poly(ADP-ribose) polymerase

P. Bauer, E. Kirsten, G. Varadi, L. J T Young, A. Hakam, J. A. Comstock, E. Kun

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A non-covalently binding inhibitory ligand of poly(ADP-ribose) polymerase, 5-iodo-6-amino-1,2-benzopyrone, when incubated at 5-600 μM external concentration with an E-ras-transformed tumorigenic cell line or with human prostatic carcinoma cells for 40 to 60 days converts both cancer cells to a non-tumorigenic phenotype that is characterized by drastic changes in cell morphology, absence of tumorigenicity in nude mice, and a high rate of aerobic glycolysis.

Original languageEnglish
Pages (from-to)374-377
Number of pages4
JournalBiochimie
Volume77
Issue number5
DOIs
Publication statusPublished - 1995

Fingerprint

Poly(ADP-ribose) Polymerases
Cells
Ligands
Phenotype
Transformed Cell Line
Glycolysis
Nude Mice
Carcinoma
5-iodo-6-amino-1,2-benzopyrone
Neoplasms

Keywords

  • 5-iodo-6-amino-1,2-benzopyrone
  • DU 145 cells
  • E-ras 20 cells
  • malignant phenotype
  • poly(ADP-ribose) polymerase

ASJC Scopus subject areas

  • Biochemistry

Cite this

Reversion of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone a non-covalently binding ligand of poly(ADP-ribose) polymerase. / Bauer, P.; Kirsten, E.; Varadi, G.; Young, L. J T; Hakam, A.; Comstock, J. A.; Kun, E.

In: Biochimie, Vol. 77, No. 5, 1995, p. 374-377.

Research output: Contribution to journalArticle

Bauer, P. ; Kirsten, E. ; Varadi, G. ; Young, L. J T ; Hakam, A. ; Comstock, J. A. ; Kun, E. / Reversion of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone a non-covalently binding ligand of poly(ADP-ribose) polymerase. In: Biochimie. 1995 ; Vol. 77, No. 5. pp. 374-377.
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