Reversion of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone a non-covalently binding ligand of poly(ADP-ribose) polymerase

P. I. Bauer, E. Kirsten, G. Varadi, L. J.T. Young, A. Hakam, J. A. Comstock, E. Kun

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A non-covalently binding inhibitory ligand of poly(ADP-ribose) polymerase, 5-iodo-6-amino-1,2-benzopyrone, when incubated at 5-600 μM external concentration with an E-ras-transformed tumorigenic cell line or with human prostatic carcinoma cells for 40 to 60 days converts both cancer cells to a non-tumorigenic phenotype that is characterized by drastic changes in cell morphology, absence of tumorigenicity in nude mice, and a high rate of aerobic glycolysis.

Original languageEnglish
Pages (from-to)374-377
Number of pages4
JournalBiochimie
Volume77
Issue number5
DOIs
Publication statusPublished - 1995

    Fingerprint

Keywords

  • 5-iodo-6-amino-1,2-benzopyrone
  • DU 145 cells
  • E-ras 20 cells
  • malignant phenotype
  • poly(ADP-ribose) polymerase

ASJC Scopus subject areas

  • Biochemistry

Cite this