Reversible mesoscopic model of protein adsorption: From equilibrium to dynamics

G. J. Szöllosi, I. Derényi, J. Vörös

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We present a thermodynamically consistent mesoscopic model of protein adsorption at liquid-solid interfaces. First describing the equilibrium state under varying protein concentration of the solution and binding conditions, we predict a non-trivial (non-monotonic) dependence of the experimentally observable properties of the adsorbed layer (such as the surface density and surface coverage) on these parameters. We subsequently proceed to develop a dynamical model consistent with the equilibrium description, which qualitatively reproduces known experimental phenomena and offers a promising way of studying the exchange of the adsorbed proteins by the proteins of the solution.

Original languageEnglish
Pages (from-to)359-375
Number of pages17
JournalPhysica A: Statistical Mechanics and its Applications
Volume343
Issue number1-4
DOIs
Publication statusPublished - Nov 15 2004

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Keywords

  • Equilibrium model
  • Protein adsorption
  • Reversible adsorption

ASJC Scopus subject areas

  • Statistics and Probability
  • Condensed Matter Physics

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