Reversible disulphide formation in polymer networks

A versatile functional group from synthesis to applications

Benjámin Gyarmati, Árpád Némethy, András Szilágyi

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

A substantial effort has been made in the last few decades to develop responsive materials that produce a selective answer to well-defined environmental stimuli. In our present review, we focus on the chemistry of thiol-disulphide equilibrium and its incorporation into polymer-based soft materials. Because several papers and extensive reviews have focused on reduction-sensitive drug delivery and gene transfer, we would like to especially emphasise the importance of disulphide formation and the exploitation of reversible thiol-disulphide interconversion in synthesis and its applications. We report the most important synthetic strategies that utilise disulphide formation. However, a major portion of our overview will concentrate on taking advantage of the thiol-disulphide exchange and the reversibility of this reaction in a wide range of applications, such as advanced drug delivery vehicles, bioartificial implants and self-healing and shape-imprinting polymers. In certain cases, the reversibility is only proven and used in one cycle, but in some cases, the process is practically reversible, at least in the time range of the dedicated application. The reversibility of the reaction is an important requirement for the long-term use of these polymers as implant materials; therefore, aside from better understanding the redox processes in living cells, the future direction of this research can lead to the improvement of reversible responses.

Original languageEnglish
Pages (from-to)1268-1286
Number of pages19
JournalEuropean Polymer Journal
Volume49
Issue number6
DOIs
Publication statusPublished - Jun 2013

Fingerprint

disulfides
Disulfides
Functional groups
Polymers
Drug delivery
Sulfhydryl Compounds
thiols
polymers
synthesis
Gene transfer
delivery
drugs
Cells
healing
exploitation
genes
stimuli
vehicles
chemistry
requirements

Keywords

  • Disulphide
  • Drug delivery
  • Hydrogels
  • Redox sensitivity
  • Self-healing
  • Thiolated polymers

ASJC Scopus subject areas

  • Polymers and Plastics
  • Physics and Astronomy(all)
  • Organic Chemistry

Cite this

Reversible disulphide formation in polymer networks : A versatile functional group from synthesis to applications. / Gyarmati, Benjámin; Némethy, Árpád; Szilágyi, András.

In: European Polymer Journal, Vol. 49, No. 6, 06.2013, p. 1268-1286.

Research output: Contribution to journalArticle

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