Reversibility of cisternal stack formation during hypoxic hypoxia and subsequent reoxygenation in cerebellar Purkinje cells

Takeshi Ikemoto, Hiroshi Yorifuji, Tetsuo Satoh, E. Sylvester Vizi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Cisternal stacks are induced during hypoxia, which may be associated with intracellular Ca2+ regulation. Although neurons are divided internally in different compartments, little is known about regional differences in cisternal stack formation. We investigated the effects of hypoxic hypoxia and later reoxygenation on cisternal stack formation and other ultrastructual changes in the proximal dendrite, dendritic spine, and cell body of cerebellar Purkinje cells in rats. After brief hypoxic events, cisternal stacks appeared predominantly in the proximal dendrites and after longer hypoxic events in dendritic spines and cell body. Following reoxygenation, cisternal stacks disappeared first in the cell body, followed by the dendritic spines, then the proximal dendrites. These results showed that stack formation occurred at different degrees and time courses among the three regions, and the effect was reversible, which suggests that these compartments are differentially sensitive to hypoxia.

Original languageEnglish
Pages (from-to)1535-1542
Number of pages8
JournalNeurochemical research
Volume28
Issue number10
DOIs
Publication statusPublished - Oct 1 2003

Keywords

  • Cerebellar Purkinje cell
  • Cisternal stack
  • Hypoxia
  • Rat
  • Reoxygenation

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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