Reversed-phase thin-layer chromatographic determination of the hydrophobicity parameters of nonsteroidal anti-inflammatory drugs

Esther Forgács, Tibor Cserháti, Roman Kaliszan, Peter Haber, Anton Nasal

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The lipophilicity and specific hydrophobic surface area of eighteen nonsteroidal anti-inflammatory drugs have been determined by reversed-phase thin-layer chromatography for subsequent studies of quantitative structure- activity relationships (QSAR). The mobile phases were mixtures of water and methanol containing 50 mM acetic acid, sodium acetate, or sodium chloride. The lipophilicity and specific hydrophobic surface area were calculated from the linear relationship between the actual R(M) value of the solutes and the concentration of methanol in the mobile phase. The spectral mapping technique indicated that eluent additives increase the apparent lipophilicity and specific hydrophobic surface area of nonsteroidal anti-inflammatory drugs. The hydrophobicity parameters were well separated according to the character of the eluent additives. Because the two-dimensional nonlinear selectivity map indicated that acetic acid, sodium acetate, and sodium chloride have different effects on the hydrophobicity parameters of the drugs, their inclusion as separate molecular characteristics in QSAR calculation is proposed.

Original languageEnglish
Pages (from-to)383-387
Number of pages5
JournalJournal of Planar Chromatography - Modern TLC
Volume11
Issue number5
Publication statusPublished - Sep 1 1998

Keywords

  • Nonsteroidal anti- Inflammatory drugs (NSAIDs)
  • Quantitative structure-activity relationships (QSAR)
  • Reversed-phase TLC
  • Specific hydrophobic surface area
  • Spectral mapping

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

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