Reversed phase thin layer chromatographic behavior of some acylanilide fungicides

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4 Citations (Scopus)


The Rf values of some acylanilide derivatives was determined under reversed phase thin layer chromatographic (RP-TLC) conditions using acetone-water and methanol-water mixtures as mobile phases. The RM0 and b values related to the molecular lipophilicity and to the specific hydrophobic surface area of the analytes were calculated. The relationships between the chromatographic parameters and physicochemical characteristics were calculated by principal component analysis (PCA), cluster analysis (CA), and stepwise linear regression analysis. The results indicated that the type of organic modifier exerts a negligible effect on the measured RP-TLC parameters. It was further established that the results of PCA cannot be used for differentiation among the physicochemical parameters. CA calculations indicated that the highest similarities were between metalaxyl and furalaxyl, as well as between oxadixyl and RE26745. Stepwise regression analysis proved that computed parameters can be successfully used for the prediction of the retention behavior of acylanilide derivatives in RP-TLC.

Original languageEnglish
Pages (from-to)1317-1330
Number of pages14
JournalJournal of Liquid Chromatography and Related Technologies
Issue number9
Publication statusPublished - Oct 19 2009


  • Acylanilide fungicides
  • Quantitative structure-retention relationship (QSRR)
  • Reversed phase thin layer chromatography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Pharmaceutical Science
  • Clinical Biochemistry

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