Reversed-phase chromatographic study of the binding of polychlorinated biphenyls to cyclodextrins and sodium dodecylsulphate

Esther Forgács, Katerina Demnerová

Research output: Contribution to journalArticle

Abstract

The binding of polychlorinated biphenyls (PCBs) to hydroxypropyl-β-cyclodextrin (HP-β-CD), τ-cyclodextrin (τ-CD) and sodium dodecylsulphate (SDS) was studied by reversed phase thin-layer chromatography and the relative strength of interaction was calculated. HP-β-CD and SDS did not bind to PCBs making it unlikely that these compounds modify the adsorption capacity or decomposition rate of PCBs. Each PCB formed inclusion complexes with τ-cyclodextrin. The inclusion-forming capacity of PCBs increased with an increase in the number of chloro substitutions in the molecule, indicating that τ-CD can be successfully used for the modification of the physicochemical and biochemical characteristics of PCBs. The linear correlation between the hydrophobicity and specific hydrophobic surface area of PCBs indicated that they can be considered as a homologous series of compounds.

Original languageEnglish
Pages (from-to)92-94
Number of pages3
JournalBiomedical Chromatography
Volume10
Issue number2
DOIs
Publication statusPublished - Mar 1 1996

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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