Reverse pinocytosis induced in cerebral endothelial cells by injection of histamine into the cerebral ventricle

E. Dux, T. Dóczi, F. Joó, P. Szerdahelyi, L. Siklós

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Abstract

Histamine dihydrochloride (10 μg of 500 μg/ml) was infused during 1 min into the lateral cerebral ventricle of rats, which resulted in a significant stimulation of pinocytosis in the endothelial cells. Systemic injections of mepyramine or metiamide could not prevent this activation. In contrast, ranitidine, injected with histamine was able to inhibit the stimulation of pinocytosis. Albumin exudation from the blood was not found. There was also no change in water and electrolyte contents of the brain tissue. The results suggest that histamine reaching the abluminal membrane can activate the pinocytosis in the cerebral endothelial cells in the reverse direction, i.e., from brain to blood, without opening the blood-brain barrier.

Original languageEnglish
Pages (from-to)484-488
Number of pages5
JournalActa neuropathologica
Volume76
Issue number5
DOIs
Publication statusPublished - Sep 1 1988

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Keywords

  • Brain-blood barrier
  • Cerebral ventricle
  • Histamine
  • Pinocytosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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