Abstract
A study on the hydrogenation of ethyl pyruvate, methyl benzoylformate and 2,2,2-trifluoroacetophenone over Pt-cinchona alkaloid chiral catalysts and over the "unmodified" catalysts resulted after a cleaning step at 323 K of the chirally modified surfaces in continuous-flow fixed-bed reactor system is presented. According to these investigations the sense of the residual ee observed in the reactions carried out in the absence of modifiers over the catalysts rinsed after the chiral hydrogenations was influenced by the solvent and the structure of the activated ketone, pointing on the effect of these parameters on the structure of the adsorbed intermediate complexes and implicitly on the chiral induction.
| Original language | English |
|---|---|
| Pages (from-to) | 14-19 |
| Number of pages | 6 |
| Journal | Catalysis Communications |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Oct 25 2010 |
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Keywords
- Activated ketones
- Asymmetric hydrogenation
- Cinchona alkaloids
- Flow reactor
- Platinum
- Reversal of ee
ASJC Scopus subject areas
- Catalysis
- Process Chemistry and Technology
- Chemistry(all)
Cite this
Reversal of the ee in enantioselective hydrogenation of activated ketones in continuous-flow fixed-bed reactor system. / Cserényi, S.; Szöllősi, G.; Szöri, K.; Fülöp, F.; Bartók, M.
In: Catalysis Communications, Vol. 12, No. 1, 25.10.2010, p. 14-19.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reversal of the ee in enantioselective hydrogenation of activated ketones in continuous-flow fixed-bed reactor system
AU - Cserényi, S.
AU - Szöllősi, G.
AU - Szöri, K.
AU - Fülöp, F.
AU - Bartók, M.
PY - 2010/10/25
Y1 - 2010/10/25
N2 - A study on the hydrogenation of ethyl pyruvate, methyl benzoylformate and 2,2,2-trifluoroacetophenone over Pt-cinchona alkaloid chiral catalysts and over the "unmodified" catalysts resulted after a cleaning step at 323 K of the chirally modified surfaces in continuous-flow fixed-bed reactor system is presented. According to these investigations the sense of the residual ee observed in the reactions carried out in the absence of modifiers over the catalysts rinsed after the chiral hydrogenations was influenced by the solvent and the structure of the activated ketone, pointing on the effect of these parameters on the structure of the adsorbed intermediate complexes and implicitly on the chiral induction.
AB - A study on the hydrogenation of ethyl pyruvate, methyl benzoylformate and 2,2,2-trifluoroacetophenone over Pt-cinchona alkaloid chiral catalysts and over the "unmodified" catalysts resulted after a cleaning step at 323 K of the chirally modified surfaces in continuous-flow fixed-bed reactor system is presented. According to these investigations the sense of the residual ee observed in the reactions carried out in the absence of modifiers over the catalysts rinsed after the chiral hydrogenations was influenced by the solvent and the structure of the activated ketone, pointing on the effect of these parameters on the structure of the adsorbed intermediate complexes and implicitly on the chiral induction.
KW - Activated ketones
KW - Asymmetric hydrogenation
KW - Cinchona alkaloids
KW - Flow reactor
KW - Platinum
KW - Reversal of ee
UR - http://www.scopus.com/inward/record.url?scp=77955972853&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955972853&partnerID=8YFLogxK
U2 - 10.1016/j.catcom.2010.08.008
DO - 10.1016/j.catcom.2010.08.008
M3 - Article
AN - SCOPUS:77955972853
VL - 12
SP - 14
EP - 19
JO - Catalysis Communications
JF - Catalysis Communications
SN - 1566-7367
IS - 1
ER -