Reversal of neuromuscular effects of adenosine by specific adenosine A1-receptor antagonist in live rats

Keiichi Nitahara, E. Sylvester Vizi, Shinjiro Shono, Mari Iihoshi, Hideyuki Higuchi, Kazuo Higa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Intravenous adenosine in-vivo was shown to potentiate the effects of non-depolarizing neuromuscular blocking agents. This study aimed to determine whether adenosine A1-receptors mediated this potentiation. The authors investigated the effects of intravenous adenosine, N6- cyclopentyladenosine, specific A1-receptor agonist, and 8-cyclopentyl-1,3- dipropylxanthine, specific A1-receptor antagonist, on neuromuscular block by vecuronium, in in-vivo rat sciatic nerve-tibialis anterior preparations. In the presence of 50% steady state block by vecuronium, adenosine, and N 6-cyclopentyladenosine caused similar degree of depressions of twitch tension. Twitch tension returned to its pre-injection value more rapidly when 8-cyclopentyl-1,3-dipropylxanthine was given at the maximal block than when it was allowed to recover spontaneously. It was concluded that in in-vivo adenosine potentiated the neuromuscular effects of vecuronium through adenosine A1-receptors in rats.

Original languageEnglish
Pages (from-to)405-410
Number of pages6
JournalInternational Journal of Neuroscience
Volume115
Issue number3
DOIs
Publication statusPublished - Mar 1 2005

Keywords

  • Adenosine
  • N(6)-cyclopentyladenosine
  • Neuromuscular blocking agents
  • Purinergic P1
  • Receptors: adenosine A1
  • Vecuronium

ASJC Scopus subject areas

  • Neuroscience(all)

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