Reversal of multidrug resistance and computational studies of pistagremic acid isolated from Pistacia integerrima

Abdur Rauf, Ghias Uddin, Muslim Raza, Aftab Ahmad, Noor Jehan, Bashir Ahmad, Muhammad Nisar, J. Molnár, Akos Csonka, Diana Szabo, Ajmal Khan, Umar Farooq, Mah Noor

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Pistagremic acid (PA) is a bioactive triterpenoid isolated from various parts of Pistacia integerrima plants. The aim of this research was to investigate PA for reversion of multidrug resistant (MDR) mediated by P-glycoprotein using rhodamine-123 exclusion study on a multidrug resistant human ABCB1 (ATP-binding cassette, sub-family B, member 1) gene-transfected mouse T-lymphoma cell line in vitro. Results were similar to those with verapamil as a positive control. Docking studies of PA and standard Rhodamine123 were carried out against a P-gp crystal structure which showed satisfactory results. Actually, PA cannot bind exactly where co-crystallized ligand of P-gp is already present. However, the docking study predicted that if a compound gives a lesser score then it may have some potency. The docking scores of PA and Rhodamine were similar. Therefore, we can conclude that there are certain important chemical features of PA which are responsible for the inhibiting potency of P-gp.

Original languageEnglish
Pages (from-to)2311-2314
Number of pages4
JournalAsian Pacific Journal of Cancer Prevention
Volume17
Issue number4
DOIs
Publication statusPublished - 2016

Fingerprint

Pistacia
Multiple Drug Resistance
P-Glycoprotein
Rhodamine 123
Rhodamines
Verapamil
pistagremic acid
Lymphoma
Ligands
Cell Line
Research
Genes

Keywords

  • Molecular
  • Pistacia integerrima
  • Pistagremic acid
  • Reversal of MDR in mouse lymphoma cells activities

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

Reversal of multidrug resistance and computational studies of pistagremic acid isolated from Pistacia integerrima. / Rauf, Abdur; Uddin, Ghias; Raza, Muslim; Ahmad, Aftab; Jehan, Noor; Ahmad, Bashir; Nisar, Muhammad; Molnár, J.; Csonka, Akos; Szabo, Diana; Khan, Ajmal; Farooq, Umar; Noor, Mah.

In: Asian Pacific Journal of Cancer Prevention, Vol. 17, No. 4, 2016, p. 2311-2314.

Research output: Contribution to journalArticle

Rauf, A, Uddin, G, Raza, M, Ahmad, A, Jehan, N, Ahmad, B, Nisar, M, Molnár, J, Csonka, A, Szabo, D, Khan, A, Farooq, U & Noor, M 2016, 'Reversal of multidrug resistance and computational studies of pistagremic acid isolated from Pistacia integerrima', Asian Pacific Journal of Cancer Prevention, vol. 17, no. 4, pp. 2311-2314. https://doi.org/10.7314/APJCP.2016.17.4.2311
Rauf, Abdur ; Uddin, Ghias ; Raza, Muslim ; Ahmad, Aftab ; Jehan, Noor ; Ahmad, Bashir ; Nisar, Muhammad ; Molnár, J. ; Csonka, Akos ; Szabo, Diana ; Khan, Ajmal ; Farooq, Umar ; Noor, Mah. / Reversal of multidrug resistance and computational studies of pistagremic acid isolated from Pistacia integerrima. In: Asian Pacific Journal of Cancer Prevention. 2016 ; Vol. 17, No. 4. pp. 2311-2314.
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