Retrospective survey on the prevalence and outcome of prior autoimmune diseases in patients with aplastic anemia reported to the registry of the european group for blood and marrow transplantation

Simone Cesaro, Judith Marsh, Gloria Tridello, Alicia Rovò, Sebastien Maury, Barbara Montante, T. Masszi, Maria Teresa Van Lint, Boris Afanasyev, Arturo Iriondo Atienza, Marc Bierings, Cecilia Carbone, Michael Doubek, Edoardo Lanino, Mahmoud Sarhan, Antonio Risitano, Katerina Steinerova, Anders Wahlin, Anna Pegoraro, Jakob Passweg

Research output: Contribution to journalArticle

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Abstract

Background: Aplastic anemia (AA) is rarely described after a diagnosis of autoimmune disease (aID). Aims: To assess the prevalence of prior aID in patients with AA recorded in the registry of the European Group for Blood and Marrow Transplantation (EBMT) and to evaluate treatment and outcome. Methods: 1,251 AA patients from 18 EBMT centers were assessed. Results: Fifty patients (4%) were eligible: 22 males and 28 females with a median age of 46 years at the diagnosis of aID and of 51 years at the diagnosis of AA. Information on the treatment of AA was available in 49 patients: 38 received only immunosuppressive therapy (IST), 8 patients underwent hematopoietic stem cell transplantation (HSCT) - 6 as first-line therapy and 2 after failure of IST - whilst 3 patients had a spontaneous recovery. After a median follow-up of 3.19 years, 32 patients were alive, including 7 of the 8 patients who underwent HSCT. Only 6 of 32 patients who were alive at the last follow-up were receiving IST for AA. Conclusions: Most cases of AA following aID benefitted from IST or HSCT if a matched donor was available. Further prospective investigation is needed to assess the effects of IST on the outcome of underlying aID.

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalActa Haematologica
Volume124
Issue number1
DOIs
Publication statusPublished - Jul 2010

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Aplastic Anemia
Blood Group Antigens
Autoimmune Diseases
Registries
Transplantation
Bone Marrow
Immunosuppressive Agents
Hematopoietic Stem Cell Transplantation
Therapeutics
Surveys and Questionnaires
Tissue Donors

Keywords

  • Aplastic anemia
  • Autoimmune disease
  • Hematopoietic stem cell transplantation
  • Immunosuppression

ASJC Scopus subject areas

  • Hematology

Cite this

Retrospective survey on the prevalence and outcome of prior autoimmune diseases in patients with aplastic anemia reported to the registry of the european group for blood and marrow transplantation. / Cesaro, Simone; Marsh, Judith; Tridello, Gloria; Rovò, Alicia; Maury, Sebastien; Montante, Barbara; Masszi, T.; Van Lint, Maria Teresa; Afanasyev, Boris; Iriondo Atienza, Arturo; Bierings, Marc; Carbone, Cecilia; Doubek, Michael; Lanino, Edoardo; Sarhan, Mahmoud; Risitano, Antonio; Steinerova, Katerina; Wahlin, Anders; Pegoraro, Anna; Passweg, Jakob.

In: Acta Haematologica, Vol. 124, No. 1, 07.2010, p. 19-22.

Research output: Contribution to journalArticle

Cesaro, S, Marsh, J, Tridello, G, Rovò, A, Maury, S, Montante, B, Masszi, T, Van Lint, MT, Afanasyev, B, Iriondo Atienza, A, Bierings, M, Carbone, C, Doubek, M, Lanino, E, Sarhan, M, Risitano, A, Steinerova, K, Wahlin, A, Pegoraro, A & Passweg, J 2010, 'Retrospective survey on the prevalence and outcome of prior autoimmune diseases in patients with aplastic anemia reported to the registry of the european group for blood and marrow transplantation', Acta Haematologica, vol. 124, no. 1, pp. 19-22. https://doi.org/10.1159/000313783
Cesaro, Simone ; Marsh, Judith ; Tridello, Gloria ; Rovò, Alicia ; Maury, Sebastien ; Montante, Barbara ; Masszi, T. ; Van Lint, Maria Teresa ; Afanasyev, Boris ; Iriondo Atienza, Arturo ; Bierings, Marc ; Carbone, Cecilia ; Doubek, Michael ; Lanino, Edoardo ; Sarhan, Mahmoud ; Risitano, Antonio ; Steinerova, Katerina ; Wahlin, Anders ; Pegoraro, Anna ; Passweg, Jakob. / Retrospective survey on the prevalence and outcome of prior autoimmune diseases in patients with aplastic anemia reported to the registry of the european group for blood and marrow transplantation. In: Acta Haematologica. 2010 ; Vol. 124, No. 1. pp. 19-22.
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AU - Montante, Barbara

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AU - Doubek, Michael

AU - Lanino, Edoardo

AU - Sarhan, Mahmoud

AU - Risitano, Antonio

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