A jellemzo laboratóriumi eltérések alakulása HELLP (haemolysis, elevated liver enzymes, low platelet count) szindrómával szövodött terhességekben

Translated title of the contribution: Retrospective study of perioperative treatment in patients with HELLP syndrome

P. Hupuczi, Ervin Hruby, Barbara Rigó, I. Sziller, B. Nagy, Z. Papp

Research output: Contribution to journalArticle

Abstract

Introduction: HELLP syndrome (Haemolysis, Elevated Liver enzymes, Low platelet count) is a severe, life threatening form of preeclampsia, which was named by Weinstein in 1982, on the basis of characteristic changes in laboratory findings (haemolysis, elevated level of liver enzymes and thrombocytopenia). Its development is accompanied by a significant increase in maternal and foetal morbidity and mortality alike, therefore it is essential that obstetricians are familiar with the disease. Material and Methods: In the past ten years, 107 patients were treated for HELLP syndrome at the Intensive Care Unit (ICU) of the 1st Department of Obstetrics and Gynaecology, Semmelweis University. In our article we summed up about our experience with the treatment of patients, with special regard to the typical symptoms of HELLP syndrome, the laboratory abnormalities and the course of the disease. Results: The frequency of HELLP syndrome in live births was found to be 0.37% at our department. In our sample, among the liver enzymes, AST and LDH, the level of total bilirubin (indicating the degree of haemolysis), and repeated thrombocyte counts were suitable for following up the clinical course of HELLP syndrome. Among the patients who recovered from this disease, the AST, LDH and bilirubin levels returned to normal on the 4-5th days, 6-7th days and 3rd day, respectively, while the platelet count reached the critical level at 100 000/μl on the 3-4th days. Conclusions: The immediate termination of a pregnancy in which HELLP syndrome emerges may save the patient's life. Significant differences could be observed among the three groups in the thrombocyte count, LDH, AST and total bilirubin. The differences are especially great because the values fall in a very wide range. On admission, the mean haematocrit level was in the normal range in all of the groups, then it decreased, but the subsequent increase could be due to the high rate of transfusions.

Original languageHungarian
Pages (from-to)517-528
Number of pages12
JournalMagyar Noorvosok Lapja
Volume69
Issue number6
Publication statusPublished - 2006

Fingerprint

HELLP Syndrome
Retrospective Studies
Hemolysis
Bilirubin
Platelet Count
Liver
Enzymes
Therapeutics
Blood Platelets
Fetal Mortality
Hospital Obstetrics and Gynecology Department
Live Birth
Pre-Eclampsia
Gynecology
Hematocrit
Thrombocytopenia
Intensive Care Units
Reference Values
Mothers
Morbidity

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

@article{f9ea96cebeb94b20b26b135f45441575,
title = "A jellemzo laborat{\'o}riumi elt{\'e}r{\'e}sek alakul{\'a}sa HELLP (haemolysis, elevated liver enzymes, low platelet count) szindr{\'o}m{\'a}val sz{\"o}vod{\"o}tt terhess{\'e}gekben",
abstract = "Introduction: HELLP syndrome (Haemolysis, Elevated Liver enzymes, Low platelet count) is a severe, life threatening form of preeclampsia, which was named by Weinstein in 1982, on the basis of characteristic changes in laboratory findings (haemolysis, elevated level of liver enzymes and thrombocytopenia). Its development is accompanied by a significant increase in maternal and foetal morbidity and mortality alike, therefore it is essential that obstetricians are familiar with the disease. Material and Methods: In the past ten years, 107 patients were treated for HELLP syndrome at the Intensive Care Unit (ICU) of the 1st Department of Obstetrics and Gynaecology, Semmelweis University. In our article we summed up about our experience with the treatment of patients, with special regard to the typical symptoms of HELLP syndrome, the laboratory abnormalities and the course of the disease. Results: The frequency of HELLP syndrome in live births was found to be 0.37{\%} at our department. In our sample, among the liver enzymes, AST and LDH, the level of total bilirubin (indicating the degree of haemolysis), and repeated thrombocyte counts were suitable for following up the clinical course of HELLP syndrome. Among the patients who recovered from this disease, the AST, LDH and bilirubin levels returned to normal on the 4-5th days, 6-7th days and 3rd day, respectively, while the platelet count reached the critical level at 100 000/μl on the 3-4th days. Conclusions: The immediate termination of a pregnancy in which HELLP syndrome emerges may save the patient's life. Significant differences could be observed among the three groups in the thrombocyte count, LDH, AST and total bilirubin. The differences are especially great because the values fall in a very wide range. On admission, the mean haematocrit level was in the normal range in all of the groups, then it decreased, but the subsequent increase could be due to the high rate of transfusions.",
keywords = "HELLP syndrome, Laboratory abnormalities, Mississippi classification",
author = "P. Hupuczi and Ervin Hruby and Barbara Rig{\'o} and I. Sziller and B. Nagy and Z. Papp",
year = "2006",
language = "Hungarian",
volume = "69",
pages = "517--528",
journal = "Magyar Noorvosok Lapja",
issn = "0025-021X",
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TY - JOUR

T1 - A jellemzo laboratóriumi eltérések alakulása HELLP (haemolysis, elevated liver enzymes, low platelet count) szindrómával szövodött terhességekben

AU - Hupuczi, P.

AU - Hruby, Ervin

AU - Rigó, Barbara

AU - Sziller, I.

AU - Nagy, B.

AU - Papp, Z.

PY - 2006

Y1 - 2006

N2 - Introduction: HELLP syndrome (Haemolysis, Elevated Liver enzymes, Low platelet count) is a severe, life threatening form of preeclampsia, which was named by Weinstein in 1982, on the basis of characteristic changes in laboratory findings (haemolysis, elevated level of liver enzymes and thrombocytopenia). Its development is accompanied by a significant increase in maternal and foetal morbidity and mortality alike, therefore it is essential that obstetricians are familiar with the disease. Material and Methods: In the past ten years, 107 patients were treated for HELLP syndrome at the Intensive Care Unit (ICU) of the 1st Department of Obstetrics and Gynaecology, Semmelweis University. In our article we summed up about our experience with the treatment of patients, with special regard to the typical symptoms of HELLP syndrome, the laboratory abnormalities and the course of the disease. Results: The frequency of HELLP syndrome in live births was found to be 0.37% at our department. In our sample, among the liver enzymes, AST and LDH, the level of total bilirubin (indicating the degree of haemolysis), and repeated thrombocyte counts were suitable for following up the clinical course of HELLP syndrome. Among the patients who recovered from this disease, the AST, LDH and bilirubin levels returned to normal on the 4-5th days, 6-7th days and 3rd day, respectively, while the platelet count reached the critical level at 100 000/μl on the 3-4th days. Conclusions: The immediate termination of a pregnancy in which HELLP syndrome emerges may save the patient's life. Significant differences could be observed among the three groups in the thrombocyte count, LDH, AST and total bilirubin. The differences are especially great because the values fall in a very wide range. On admission, the mean haematocrit level was in the normal range in all of the groups, then it decreased, but the subsequent increase could be due to the high rate of transfusions.

AB - Introduction: HELLP syndrome (Haemolysis, Elevated Liver enzymes, Low platelet count) is a severe, life threatening form of preeclampsia, which was named by Weinstein in 1982, on the basis of characteristic changes in laboratory findings (haemolysis, elevated level of liver enzymes and thrombocytopenia). Its development is accompanied by a significant increase in maternal and foetal morbidity and mortality alike, therefore it is essential that obstetricians are familiar with the disease. Material and Methods: In the past ten years, 107 patients were treated for HELLP syndrome at the Intensive Care Unit (ICU) of the 1st Department of Obstetrics and Gynaecology, Semmelweis University. In our article we summed up about our experience with the treatment of patients, with special regard to the typical symptoms of HELLP syndrome, the laboratory abnormalities and the course of the disease. Results: The frequency of HELLP syndrome in live births was found to be 0.37% at our department. In our sample, among the liver enzymes, AST and LDH, the level of total bilirubin (indicating the degree of haemolysis), and repeated thrombocyte counts were suitable for following up the clinical course of HELLP syndrome. Among the patients who recovered from this disease, the AST, LDH and bilirubin levels returned to normal on the 4-5th days, 6-7th days and 3rd day, respectively, while the platelet count reached the critical level at 100 000/μl on the 3-4th days. Conclusions: The immediate termination of a pregnancy in which HELLP syndrome emerges may save the patient's life. Significant differences could be observed among the three groups in the thrombocyte count, LDH, AST and total bilirubin. The differences are especially great because the values fall in a very wide range. On admission, the mean haematocrit level was in the normal range in all of the groups, then it decreased, but the subsequent increase could be due to the high rate of transfusions.

KW - HELLP syndrome

KW - Laboratory abnormalities

KW - Mississippi classification

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