Retrospective clinical study of adjuvant electro-hyperthermia treatment for advanced brain-gliomas

Hüseyin Sahinbas, Dietrich H W Grönemeyer, Eckhard Böcher, A. Szász

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Malignant gliomas represent about 70 % of all brain tumors. Despite advances in standard therapy consisting of surgery, radiation therapy and chemotherapy, gliomas remain an essentially fatal disease, with a median survival time of 10 to 12 months and a 2-year survival rate of 8 % to 12 %. Electro-hyperthermia applied either alone or in combination with chemo- and/or radio-therapy is an advanced hyperthermia technique that has been used as adjuvant treatment for patients with malignant glioma. We present the results of a retrospective study of 140 patients with different stages of malignant glioma, which were treated/followed from January 2000 to February 2005. The endpoint was the overall survival and the survival from the 1st electro-hyperthermia treatment. The overall median survival time for patients with mostly advanced malignant glioma who received adjuvant electro-hyperthermia in this study was 20.4 months. The median survival time from the first electro-hyperthermia treatment was 6.6 months. Electro-hyperthermia was safe and well tolerated. The presented results show the feasibility of the treatment and suggest a benefit of the electro-hyperthermia treatment for patients with advanced malignant glioma.

Original languageEnglish
Pages (from-to)154-160
Number of pages7
JournalDeutsche Zeitschrift fur Onkologie
Volume39
Issue number4
DOIs
Publication statusPublished - 2007

Fingerprint

Glioma
Fever
Retrospective Studies
Brain
Survival
Therapeutics
Clinical Studies
Radio
Brain Neoplasms
Radiotherapy
Survival Rate
Drug Therapy

Keywords

  • Chemotherapy
  • Hyperthermia
  • Malignant glioma
  • Radiotherapy
  • Survival rates

ASJC Scopus subject areas

  • Cancer Research

Cite this

Retrospective clinical study of adjuvant electro-hyperthermia treatment for advanced brain-gliomas. / Sahinbas, Hüseyin; Grönemeyer, Dietrich H W; Böcher, Eckhard; Szász, A.

In: Deutsche Zeitschrift fur Onkologie, Vol. 39, No. 4, 2007, p. 154-160.

Research output: Contribution to journalArticle

Sahinbas, Hüseyin ; Grönemeyer, Dietrich H W ; Böcher, Eckhard ; Szász, A. / Retrospective clinical study of adjuvant electro-hyperthermia treatment for advanced brain-gliomas. In: Deutsche Zeitschrift fur Onkologie. 2007 ; Vol. 39, No. 4. pp. 154-160.
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