Ópiátfüggo várandós nok kórtörténeteinek retrospektív analízise

Translated title of the contribution: Retrospective analysis of opiate use in pregnancy

Zoltán Kovács, János Rigó

Research output: Contribution to journalReview article


The authors presented a retrospective analysis of 13 singleton pregnancies of 12 opiate addict women giving birth at the 1st Department of Obstetrics and Gynecology, Semmelweis University, between 1993-2004. We reviewed the prenatal, delivery, and neonatal records of all these women. 25% of them registered before the 20th gestational week. Six opiate-exposed mothers had psychiatric, nervous and emotional disorders (e.g.: depression, social phobia). HCV-Ab tests were positive in three heroin-dependent women. One opiate addict pregnant woman had serological evidence of a concomittant hepatitis A and C infection. HPV identification and VDRL tests were positive once. All opiate-using women were negative for HIV and HbsAg serology tests. In the third trimester of pregnancy seven women were on methadone and four on clonazepam. 13 pregnancies resulted in 13 live births (only 3 preterm deliveries). There were 3 cases of intrauterine growth retardation, one ending in preterm delivery. In the postpartum period six opiate-dependent women and their neonates had to be given substitution therapy. None of the neonates were HCV-Ab, HAV-Ab, HbsAg, VDRL, and HIV-positive. We managed to prevent stillbirth, perinatal death and the intrauterine opiate withdrawal syndrome with close monitoring of the pregnancy by a multidisciplinary team thus avoiding the risk of maternal or fetal complications.

Original languageHungarian
Pages (from-to)27-31
Number of pages5
JournalMagyar Noorvosok Lapja
Issue number1
Publication statusPublished - Mar 7 2005


ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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