Retinal and renal vascular permeability changes caused by stem cell stimulation in alloxan-induced diabetic rats, measured by extravasation of fluorescein

Zoltan Doczi-Keresztesi, J. Jung, I. Kiss, T. Mezei, L. Szabo, I. Ember

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aim: To determine whether treatment with the stem cell stimulator Olimpiq® StemxCell prevents increase of retinal and renal vascular permeability in alloxan-induced diabetic rats. Materials and Methods: Two groups of Wistar rats were made diabetic by single intraperitoneal injection of Alloxan. The third, the control group, received vehicle alone. One diabetic group received Olimpiq® StemxCell treatment for 4 weeks. The permeability of the blood-retinal barrier (BRB) and renal vessels were measured by the extravasation of fluorescein-labeled bovine serum albumin. Results: Six weeks subsequently to Alloxan injection, significantly elevated the tissue fluorescence, the renal vascular leakage and BRB breakdown was demonstrated in the diabetic group, compared to the nondiabetic group. Olimpiq® StemxCell treatment significantly reduced the BRB breakdown, tissue fluorescence, and vascular leakage. Conclusion: Olimpiq® StemxCell would be a useful choice of treatment for complications associated with increased vascular permeability of diabetes, such as retinopathy or nephropathy.

Original languageEnglish
Pages (from-to)427-435
Number of pages9
JournalIn Vivo
Volume26
Issue number3
Publication statusPublished - May 1 2012

Keywords

  • Alloxan
  • Diabetic retinopathy
  • Experimental diabetes
  • FITC-BSA
  • Nephropathy
  • Olimpiq StemxCell
  • Stem cell stimulation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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