Retention of passive avoidance behavior in rats following α- and γ-endorphin administration

Effects of post-learning treatments

G. Kovács, Béla Bohus, David De wied

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Neuropeptides related to β-endorphin (β-LPH61-91) profoundly affect avidance behavior. That γ- and α-endorphin (β-LPH61-77 and β-LPH61-76, respectively) influence memory processes, has been investigated on rats. Using a one-trial learning, step-through passive avoidance paradigm, it was found that γ-endorphin attenuates later retention of passive avoidance behavior when administered immediately or 3 h after learning; α-endorphin facilitates this response when given immediately after learning. Neither γ- nor α-endorphin influence retention when the treatment is postponed for 6 h after learning. These data are interpreted as suggesting an opposite effect of γ- and α-endorphin on consolidation processes.

Original languageEnglish
Pages (from-to)79-82
Number of pages4
JournalNeuroscience Letters
Volume22
Issue number1
DOIs
Publication statusPublished - Feb 23 1981

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Avoidance Learning
Endorphins
Learning
Neuropeptides
Retention (Psychology)

ASJC Scopus subject areas

  • Neuroscience(all)

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Retention of passive avoidance behavior in rats following α- and γ-endorphin administration : Effects of post-learning treatments. / Kovács, G.; Bohus, Béla; De wied, David.

In: Neuroscience Letters, Vol. 22, No. 1, 23.02.1981, p. 79-82.

Research output: Contribution to journalArticle

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