Retention behaviours and separation of carboxylic acids by ion-exchange chromatography

Peter Hajós, L. Nagy

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The use of high-performance suppressed ion chromatography for the separation of aliphatic carboxylic acids has become an attractive and viable method during the past years. This paper summarises and critically concludes that some new results have been achieved in separation and detection of low-molecular-mass organic anions. Theoretical and practical considerations of ion-exchange selectivity to control retention behaviour are presented. The major factors that determine the separation ability of ion-exchange chromatography (pK(a) values, the aliphatic nature and valency of solutes, eluent pH and the chemical composition of stationary phases) are discussed. The question of isocratic vs. gradient elution and different separation modes are examined briefly. The potentials and limitations of the developed methods and their specific application areas are outlined. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)27-38
Number of pages12
JournalJournal of Chromatography B: Biomedical Applications
Volume717
Issue number1-2
DOIs
Publication statusPublished - Oct 9 1998

Fingerprint

Carboxylic Acids
Chromatography
Ion exchange
Ion chromatography
Molecular mass
Anions
Chemical analysis

Keywords

  • Carboxylic acids
  • Reviews

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Retention behaviours and separation of carboxylic acids by ion-exchange chromatography. / Hajós, Peter; Nagy, L.

In: Journal of Chromatography B: Biomedical Applications, Vol. 717, No. 1-2, 09.10.1998, p. 27-38.

Research output: Contribution to journalArticle

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