Retention behaviour of some ring-substituted phenol derivatives on a porous graphitized carbon column

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Abstract

The retentions of 24 ring-substituted phenol derivatives were determined on a graphitized carbon column using unbuffered acetonitrile-water and methanol-water eluent mixtures at various organic phase concentrations. Principal component analysis calculated from both the correlation and covariance matrices was used to detect the similarities and dissimilarities between the retention behaviours of phenol derivatives. Each phenol derivative showed narrow and symmetrical peaks in each eluent. The high percentage of variance explained in the first principal component suggests that the eluents have common elution characteristics; however, according to the second principal component they showed slightly different selectivities. Calculations demonstrated that the number and not the type of substituents exerts the highest impact on the retention. Both calculation methods (based on correlation and covariance matrices) gave similar results.

Original languageEnglish
Pages (from-to)75-83
Number of pages9
JournalJournal of Chromatography A
Volume592
Issue number1-2
DOIs
Publication statusPublished - Feb 21 1992

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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