Retention behaviour of barbituric acid derivatives on a β-cyclodextrin polymer-coated silica column

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Abstract

The retentions of 45 barbituric acid derivatives were determined on a β-cyclodextrin (β-CD) polymer-coated silica column using unbuffered methanol-water, ethanol-water, acetonitrile-water, dioxane-water and tetrahydrofuran-water eluent mixtures. Stepwise regression analysis indicated that the retention of barbituric acid derivatives is mainly governed by the lipophilicity, molar refractivity (related to the solute volume) and to a lesser extent by the electronic parameters of substituents in each eluent system, suggesting the significant importance of these physico-chemical parameters in the determination of retention behaviour. The spectral map technique indicated that the solvent strength and selectivity of organic modifiers on a β-CD polymer-coated silica column depended on their bulkiness and electronic parameters, respectively.

Original languageEnglish
Pages (from-to)395-402
Number of pages8
JournalJournal of Chromatography A
Volume668
Issue number2
DOIs
Publication statusPublished - May 13 1994

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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