Retention behavior of some ring-substituted aniline derivatives on polyethylene-coated and octadecylsilica columns

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Abstract

The retention characteristics of 16 aniline derivatives were determined on polyethylene-coated and on octadecylsilica columns in methanol- 25 mM K2HPO4 mixtures at various organic phase concentrations. Good linear correlations were found on both column between logk' values ant the organic mobile phase concentration in the eluent. Stepwise regression analysis proved that not only lipophilicity but electronic parameters of aniline derivatives have significant influence on the retention of aniline derivatives on polyethylene-coated silica column. Principal component analysis indicated that the retention behaviour of PEE column slightly differs from that of ODS column. This discrepancy is probably due to the hydrophobic interactions between the polar substructures of aniline derivatives and the free silanol groups not-covered by polyethylene.

Original languageEnglish
Pages (from-to)2483-2500
Number of pages18
JournalJournal of Liquid Chromatography
Volume16
Issue number12
Publication statusPublished - 1993

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Polyethylene
Derivatives
Ants
Principal Component Analysis
Hydrophobic and Hydrophilic Interactions
Regression analysis
Silicon Dioxide
Principal component analysis
Methanol
Regression Analysis
aniline
octadecylsilica

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

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abstract = "The retention characteristics of 16 aniline derivatives were determined on polyethylene-coated and on octadecylsilica columns in methanol- 25 mM K2HPO4 mixtures at various organic phase concentrations. Good linear correlations were found on both column between logk' values ant the organic mobile phase concentration in the eluent. Stepwise regression analysis proved that not only lipophilicity but electronic parameters of aniline derivatives have significant influence on the retention of aniline derivatives on polyethylene-coated silica column. Principal component analysis indicated that the retention behaviour of PEE column slightly differs from that of ODS column. This discrepancy is probably due to the hydrophobic interactions between the polar substructures of aniline derivatives and the free silanol groups not-covered by polyethylene.",
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N2 - The retention characteristics of 16 aniline derivatives were determined on polyethylene-coated and on octadecylsilica columns in methanol- 25 mM K2HPO4 mixtures at various organic phase concentrations. Good linear correlations were found on both column between logk' values ant the organic mobile phase concentration in the eluent. Stepwise regression analysis proved that not only lipophilicity but electronic parameters of aniline derivatives have significant influence on the retention of aniline derivatives on polyethylene-coated silica column. Principal component analysis indicated that the retention behaviour of PEE column slightly differs from that of ODS column. This discrepancy is probably due to the hydrophobic interactions between the polar substructures of aniline derivatives and the free silanol groups not-covered by polyethylene.

AB - The retention characteristics of 16 aniline derivatives were determined on polyethylene-coated and on octadecylsilica columns in methanol- 25 mM K2HPO4 mixtures at various organic phase concentrations. Good linear correlations were found on both column between logk' values ant the organic mobile phase concentration in the eluent. Stepwise regression analysis proved that not only lipophilicity but electronic parameters of aniline derivatives have significant influence on the retention of aniline derivatives on polyethylene-coated silica column. Principal component analysis indicated that the retention behaviour of PEE column slightly differs from that of ODS column. This discrepancy is probably due to the hydrophobic interactions between the polar substructures of aniline derivatives and the free silanol groups not-covered by polyethylene.

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