Resveratrol loading on mesoporous silica and zeolite carriers by solid state method

M. Popova, K. Yoncheva, A. Szegedi, Y. Kalvachev, N. Benbassat, V. Mavrodinova

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The feasibility of mesoporous SBA-16 and MCM-41 materials to be used as carriers for the poorly water soluble compound Resveratrol (RES) was studied and compared with that of zeolite Y. A simple procedure of encapsulation in solid-state aiming amorphization of the drug which thus enhancing its solubility has been successfully applied. Investigations using powder XRD, N2 physisorption, ATR FT-IR and TG analysis demonstrated the effective loading of RES on the surface of the carriers. RES release in buffers with pH=1.2 and pH=6.8 demonstrated faster dissolution of the loaded drug compared to non-loaded resveratrol.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalBulgarian Chemical Communications
Volume46
Issue numberSpecial Issue A
Publication statusPublished - 2014

Fingerprint

Zeolites
Silicon Dioxide
Physisorption
Amorphization
Encapsulation
Pharmaceutical Preparations
Powders
Buffers
Dissolution
Solubility
resveratrol
Water

Keywords

  • In vitro release
  • Mesoporous silica
  • Resveratrol encapsulation
  • Zeolite Y carrier

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Popova, M., Yoncheva, K., Szegedi, A., Kalvachev, Y., Benbassat, N., & Mavrodinova, V. (2014). Resveratrol loading on mesoporous silica and zeolite carriers by solid state method. Bulgarian Chemical Communications, 46(Special Issue A), 117-122.

Resveratrol loading on mesoporous silica and zeolite carriers by solid state method. / Popova, M.; Yoncheva, K.; Szegedi, A.; Kalvachev, Y.; Benbassat, N.; Mavrodinova, V.

In: Bulgarian Chemical Communications, Vol. 46, No. Special Issue A, 2014, p. 117-122.

Research output: Contribution to journalArticle

Popova, M, Yoncheva, K, Szegedi, A, Kalvachev, Y, Benbassat, N & Mavrodinova, V 2014, 'Resveratrol loading on mesoporous silica and zeolite carriers by solid state method', Bulgarian Chemical Communications, vol. 46, no. Special Issue A, pp. 117-122.
Popova M, Yoncheva K, Szegedi A, Kalvachev Y, Benbassat N, Mavrodinova V. Resveratrol loading on mesoporous silica and zeolite carriers by solid state method. Bulgarian Chemical Communications. 2014;46(Special Issue A):117-122.
Popova, M. ; Yoncheva, K. ; Szegedi, A. ; Kalvachev, Y. ; Benbassat, N. ; Mavrodinova, V. / Resveratrol loading on mesoporous silica and zeolite carriers by solid state method. In: Bulgarian Chemical Communications. 2014 ; Vol. 46, No. Special Issue A. pp. 117-122.
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