A rezveratrol gyógyszerészi kémiája

Translated title of the contribution: Resveratrol in pharmaceutical chemistry

Orgován Gábor, B. Noszál

Research output: Contribution to journalArticle

Abstract

Resveratrol is a polyphenol that can be found in various plants, including grapes. Wines therefore also contain this compound. The famous phenomenon, named "French paradox" is considered to be an effect of resveratrol: the regular, modest consumption of red wine causes low incidence of cardiovascular diseases. Resveratrol is also reported to have anti-carcinogenic, anti-inflammatory, neuroprotective, and several further beneficial effects. As yet, resveratrol is not a registered drug in Hungary; nevertheless it is a common food supplement. Paradoxically, this is the very danger of its use: it can have harmful side-effects with several drugs. The bioavailability of resveratrol is, however, not favorable, due to its poor water-solubility and extensive metabolism. Our current knowledge is still far from being sufficient to understand its mode of action at a molecular level. Only a few of the most important physicochemical properties has been determined so far. The two major directions of pharmaceutical research of resveratrol are the elaboration of formulation systems that can improve the water solubility; the other is the development of analogous agents of enhanced effects.

Original languageHungarian
Pages (from-to)123-130
Number of pages8
JournalActa Pharmaceutica Hungarica
Volume85
Issue number4
Publication statusPublished - 2015

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ASJC Scopus subject areas

  • Pharmaceutical Science

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