Resveratrol enhances exercise training responses in rats selectively bred for high running performance

Nikolett Hart, Linda Sarga, Zsolt Csende, E. Koltai, Lauren G. Koch, Steven L. Britton, Kelvin J A Davies, Dimitris Kouretas, Barbara Wessner, Z. Radák

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

High Capacity Runner (HCR) rats have been developed by divergent artificial selection for treadmill endurance running capacity to explore an aerobic biology-disease connection. The beneficial effects of resveratrol supplementation have been demonstrated in endurance running and the antioxidant capacity of resveratrol is also demonstrated. In this study we examine whether 12. weeks of treadmill exercise training and/or resveratrol can enhance performance in HCR. Indeed, resveratrol increased aerobic performance and strength of upper limbs of these rats. Moreover, we have found that resveratrol activated the AMP-activated protein kinase, SIRT1, and mitochondrial transcription factor A (p

Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalFood and Chemical Toxicology
Volume61
DOIs
Publication statusPublished - Nov 2013

Fingerprint

resveratrol
Rats
exercise
Exercise
breeds
rats
Exercise equipment
exercise equipment
Running
Durability
AMP-activated protein kinase
AMP-Activated Protein Kinases
artificial selection
limbs (animal)
Upper Extremity
transcription factors
Antioxidants
antioxidants
Biological Sciences

Keywords

  • Endurance exercise
  • Epigenetics
  • Mitochondrial biogenesis
  • Oxidative stress
  • PGC1-alpha
  • Resveratrol

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Resveratrol enhances exercise training responses in rats selectively bred for high running performance. / Hart, Nikolett; Sarga, Linda; Csende, Zsolt; Koltai, E.; Koch, Lauren G.; Britton, Steven L.; Davies, Kelvin J A; Kouretas, Dimitris; Wessner, Barbara; Radák, Z.

In: Food and Chemical Toxicology, Vol. 61, 11.2013, p. 53-59.

Research output: Contribution to journalArticle

Hart, Nikolett ; Sarga, Linda ; Csende, Zsolt ; Koltai, E. ; Koch, Lauren G. ; Britton, Steven L. ; Davies, Kelvin J A ; Kouretas, Dimitris ; Wessner, Barbara ; Radák, Z. / Resveratrol enhances exercise training responses in rats selectively bred for high running performance. In: Food and Chemical Toxicology. 2013 ; Vol. 61. pp. 53-59.
@article{4688bd00535b4be8885dba8cbf30d9b8,
title = "Resveratrol enhances exercise training responses in rats selectively bred for high running performance",
abstract = "High Capacity Runner (HCR) rats have been developed by divergent artificial selection for treadmill endurance running capacity to explore an aerobic biology-disease connection. The beneficial effects of resveratrol supplementation have been demonstrated in endurance running and the antioxidant capacity of resveratrol is also demonstrated. In this study we examine whether 12. weeks of treadmill exercise training and/or resveratrol can enhance performance in HCR. Indeed, resveratrol increased aerobic performance and strength of upper limbs of these rats. Moreover, we have found that resveratrol activated the AMP-activated protein kinase, SIRT1, and mitochondrial transcription factor A (p",
keywords = "Endurance exercise, Epigenetics, Mitochondrial biogenesis, Oxidative stress, PGC1-alpha, Resveratrol",
author = "Nikolett Hart and Linda Sarga and Zsolt Csende and E. Koltai and Koch, {Lauren G.} and Britton, {Steven L.} and Davies, {Kelvin J A} and Dimitris Kouretas and Barbara Wessner and Z. Rad{\'a}k",
year = "2013",
month = "11",
doi = "10.1016/j.fct.2013.01.051",
language = "English",
volume = "61",
pages = "53--59",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Resveratrol enhances exercise training responses in rats selectively bred for high running performance

AU - Hart, Nikolett

AU - Sarga, Linda

AU - Csende, Zsolt

AU - Koltai, E.

AU - Koch, Lauren G.

AU - Britton, Steven L.

AU - Davies, Kelvin J A

AU - Kouretas, Dimitris

AU - Wessner, Barbara

AU - Radák, Z.

PY - 2013/11

Y1 - 2013/11

N2 - High Capacity Runner (HCR) rats have been developed by divergent artificial selection for treadmill endurance running capacity to explore an aerobic biology-disease connection. The beneficial effects of resveratrol supplementation have been demonstrated in endurance running and the antioxidant capacity of resveratrol is also demonstrated. In this study we examine whether 12. weeks of treadmill exercise training and/or resveratrol can enhance performance in HCR. Indeed, resveratrol increased aerobic performance and strength of upper limbs of these rats. Moreover, we have found that resveratrol activated the AMP-activated protein kinase, SIRT1, and mitochondrial transcription factor A (p

AB - High Capacity Runner (HCR) rats have been developed by divergent artificial selection for treadmill endurance running capacity to explore an aerobic biology-disease connection. The beneficial effects of resveratrol supplementation have been demonstrated in endurance running and the antioxidant capacity of resveratrol is also demonstrated. In this study we examine whether 12. weeks of treadmill exercise training and/or resveratrol can enhance performance in HCR. Indeed, resveratrol increased aerobic performance and strength of upper limbs of these rats. Moreover, we have found that resveratrol activated the AMP-activated protein kinase, SIRT1, and mitochondrial transcription factor A (p

KW - Endurance exercise

KW - Epigenetics

KW - Mitochondrial biogenesis

KW - Oxidative stress

KW - PGC1-alpha

KW - Resveratrol

UR - http://www.scopus.com/inward/record.url?scp=84888845709&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888845709&partnerID=8YFLogxK

U2 - 10.1016/j.fct.2013.01.051

DO - 10.1016/j.fct.2013.01.051

M3 - Article

C2 - 23422033

AN - SCOPUS:84888845709

VL - 61

SP - 53

EP - 59

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

ER -