Resveratrol: A multifunctional cytoprotective molecule

Bela Juhasz, Balazs Varga, Rudolf Gesztelyi, Adam Kemeny-Beke, Judit Zsuga, Arpad Tosaki

Research output: Contribution to journalReview article

39 Citations (Scopus)

Abstract

Several recent studies have shown the protective effects of resveratrol in various experimental conditions and pathological animal models. Clinical studies also indicate the beneficial effects of resveratrol in different human diseases. Resveratrol produces a cascade against of events from the initial death-provoking signal, DNA fragmentation, and cell death. Researchers recognized the beneficial effect of resveratrol, as an important component, of the overall injury that occurs in various disorders such as oxidative stress, myocardial injury, anticancer activity, antidiabetic activity, and antihypercholesterolemic effects. Many mechanisms have been proposed for the initiation of protective effects of resveratrol in various pathological events, and considerable evidence exists to indicate that many mediators are involved in the resveratrol- induced protection. The present review focuses on the history, and the beneficial effects and mechanisms of resveratrol in oxidative stress, myocardial injury, anticancer-, antidiabetic- and antihypercholesterolemic activities, and discusses those therapeutic tools, which warrant becoming clinically important.

Original languageEnglish
Pages (from-to)810-818
Number of pages9
JournalCurrent Pharmaceutical Biotechnology
Volume11
Issue number8
DOIs
Publication statusPublished - Dec 1 2010

Keywords

  • Resveratrol

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

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