Results of longitudinal immunological surveillance of individuals directly or indirectly infected by a single HIV seropositive donor

S. Hollán, E. Újhelyi, K. Pálóczi, J. Szelényi, Gábor Illei, Leandro Medrano, Dietmar Fuchs, Lajos István, János Szabó, D. Bánhegyi, Ferenc Várnai, A. Horváth, Helmuth Wachter, George A. Medgyesi, G. Füst

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Before the introduction of obligatory blood donor screening for HIV-antibodies in Hungary (July 1, 1986) a male homosexual blood donor infected three recipients; two of them in turn infected their spouses. The donor exhibited no HIV-associated symptoms and his permanent homosexual partner remained seronegative and PCR negative. By contrast, two of the three recipients died of AIDS and in longitudinal immunological surveillance the immune parameters of the recipients and even their spouses was found to be much worse than that of the donor. These findings suggest that a marked increase in the pathogenicity of the donor's HIV strain(s) or a selection of a virulent strain occurred upon transfusion of his blood and this HIV strain was heterosexually transmitted by the recipients to their spouses. Another less probable explanation could be the presence of a yet unknown mechanism in the donor which repressed virus replication.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalTransfusion Science
Volume11
Issue number1
DOIs
Publication statusPublished - 1990

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Immunologic Surveillance
Spouses
Tissue Donors
HIV
Blood Donors
Donor Selection
HIV Antibodies
Hungary
Virus Replication
Blood Transfusion
Virulence
Acquired Immunodeficiency Syndrome
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Immunology
  • Hematology

Cite this

Results of longitudinal immunological surveillance of individuals directly or indirectly infected by a single HIV seropositive donor. / Hollán, S.; Újhelyi, E.; Pálóczi, K.; Szelényi, J.; Illei, Gábor; Medrano, Leandro; Fuchs, Dietmar; István, Lajos; Szabó, János; Bánhegyi, D.; Várnai, Ferenc; Horváth, A.; Wachter, Helmuth; Medgyesi, George A.; Füst, G.

In: Transfusion Science, Vol. 11, No. 1, 1990, p. 73-78.

Research output: Contribution to journalArticle

Hollán, S. ; Újhelyi, E. ; Pálóczi, K. ; Szelényi, J. ; Illei, Gábor ; Medrano, Leandro ; Fuchs, Dietmar ; István, Lajos ; Szabó, János ; Bánhegyi, D. ; Várnai, Ferenc ; Horváth, A. ; Wachter, Helmuth ; Medgyesi, George A. ; Füst, G. / Results of longitudinal immunological surveillance of individuals directly or indirectly infected by a single HIV seropositive donor. In: Transfusion Science. 1990 ; Vol. 11, No. 1. pp. 73-78.
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