Restraint stress and anti-tumor immune response in mice

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Psychological stress modulates the immune system through the hypothalamic-pituitary-adrenal axis, the sympatho-adrenomedullary axis and the opioid system. According to literature data, restraint stress increases the immune cell apoptosis, decreases the spleen and thymus cell content, the natural killer (NK) activity in the spleen, and it compromises the anti-tumor immune response in mice. We immobilized mice in two consecutive nights, and then determined the cell number, apoptosis, NK cell content, NK activity and the level of cytokine mRNAs (TNF-β, TNF-α, IL-4, IL-5, IL-1α, IFN-γ, IL-2, IL-6, IL-1β and IL-3) in the thymus and spleen. No consistent changes were detected in any of the immune parameters either in C57B1/6 or in DBA/2 mice. Stressed or control B6 mice were injected with B16 melanoma cells immediately after the immobilization or one week later. No significant differences were found in the growth of primary tumors and lung metastases in stressed and control animals. Taken together, our mice, kept in a general-purpose non-SPF animal house, seemed to be refractory to the stress-induced immunomodulation. Our interpretation is that stress-induced immunomodulation can occur only in mice isolated from any background stressors, or rather natural stimuli, throughout their life.

Original languageEnglish
Pages (from-to)167-176
Number of pages10
JournalActa Biologica Hungarica
Volume54
Issue number2
DOIs
Publication statusPublished - 2003

Fingerprint

immune response
tumor
Tumors
Thymus
apoptosis
Interleukin-1
neoplasms
mice
Animals
Spleen
Immunomodulation
Apoptosis
Neoplasms
spleen
immunomodulation
Natural Killer Cells
animal
Interleukin-3
Immune system
Thymus Gland

Keywords

  • Apoptosis
  • NK cells
  • Opioids
  • Psychological stress
  • Tumor immunity

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Restraint stress and anti-tumor immune response in mice. / Posevitz, V.; Vízler, C.; Benyhe, S.; Duda, E.; Borsodi, A.

In: Acta Biologica Hungarica, Vol. 54, No. 2, 2003, p. 167-176.

Research output: Contribution to journalArticle

@article{cf8359e3c500461cbc41cadadb191cbe,
title = "Restraint stress and anti-tumor immune response in mice",
abstract = "Psychological stress modulates the immune system through the hypothalamic-pituitary-adrenal axis, the sympatho-adrenomedullary axis and the opioid system. According to literature data, restraint stress increases the immune cell apoptosis, decreases the spleen and thymus cell content, the natural killer (NK) activity in the spleen, and it compromises the anti-tumor immune response in mice. We immobilized mice in two consecutive nights, and then determined the cell number, apoptosis, NK cell content, NK activity and the level of cytokine mRNAs (TNF-β, TNF-α, IL-4, IL-5, IL-1α, IFN-γ, IL-2, IL-6, IL-1β and IL-3) in the thymus and spleen. No consistent changes were detected in any of the immune parameters either in C57B1/6 or in DBA/2 mice. Stressed or control B6 mice were injected with B16 melanoma cells immediately after the immobilization or one week later. No significant differences were found in the growth of primary tumors and lung metastases in stressed and control animals. Taken together, our mice, kept in a general-purpose non-SPF animal house, seemed to be refractory to the stress-induced immunomodulation. Our interpretation is that stress-induced immunomodulation can occur only in mice isolated from any background stressors, or rather natural stimuli, throughout their life.",
keywords = "Apoptosis, NK cells, Opioids, Psychological stress, Tumor immunity",
author = "V. Posevitz and C. V{\'i}zler and S. Benyhe and E. Duda and A. Borsodi",
year = "2003",
doi = "10.1556/ABiol.54.2003.2.5",
language = "English",
volume = "54",
pages = "167--176",
journal = "Acta Biologica Hungarica",
issn = "0236-5383",
publisher = "Akademiai Kiado",
number = "2",

}

TY - JOUR

T1 - Restraint stress and anti-tumor immune response in mice

AU - Posevitz, V.

AU - Vízler, C.

AU - Benyhe, S.

AU - Duda, E.

AU - Borsodi, A.

PY - 2003

Y1 - 2003

N2 - Psychological stress modulates the immune system through the hypothalamic-pituitary-adrenal axis, the sympatho-adrenomedullary axis and the opioid system. According to literature data, restraint stress increases the immune cell apoptosis, decreases the spleen and thymus cell content, the natural killer (NK) activity in the spleen, and it compromises the anti-tumor immune response in mice. We immobilized mice in two consecutive nights, and then determined the cell number, apoptosis, NK cell content, NK activity and the level of cytokine mRNAs (TNF-β, TNF-α, IL-4, IL-5, IL-1α, IFN-γ, IL-2, IL-6, IL-1β and IL-3) in the thymus and spleen. No consistent changes were detected in any of the immune parameters either in C57B1/6 or in DBA/2 mice. Stressed or control B6 mice were injected with B16 melanoma cells immediately after the immobilization or one week later. No significant differences were found in the growth of primary tumors and lung metastases in stressed and control animals. Taken together, our mice, kept in a general-purpose non-SPF animal house, seemed to be refractory to the stress-induced immunomodulation. Our interpretation is that stress-induced immunomodulation can occur only in mice isolated from any background stressors, or rather natural stimuli, throughout their life.

AB - Psychological stress modulates the immune system through the hypothalamic-pituitary-adrenal axis, the sympatho-adrenomedullary axis and the opioid system. According to literature data, restraint stress increases the immune cell apoptosis, decreases the spleen and thymus cell content, the natural killer (NK) activity in the spleen, and it compromises the anti-tumor immune response in mice. We immobilized mice in two consecutive nights, and then determined the cell number, apoptosis, NK cell content, NK activity and the level of cytokine mRNAs (TNF-β, TNF-α, IL-4, IL-5, IL-1α, IFN-γ, IL-2, IL-6, IL-1β and IL-3) in the thymus and spleen. No consistent changes were detected in any of the immune parameters either in C57B1/6 or in DBA/2 mice. Stressed or control B6 mice were injected with B16 melanoma cells immediately after the immobilization or one week later. No significant differences were found in the growth of primary tumors and lung metastases in stressed and control animals. Taken together, our mice, kept in a general-purpose non-SPF animal house, seemed to be refractory to the stress-induced immunomodulation. Our interpretation is that stress-induced immunomodulation can occur only in mice isolated from any background stressors, or rather natural stimuli, throughout their life.

KW - Apoptosis

KW - NK cells

KW - Opioids

KW - Psychological stress

KW - Tumor immunity

UR - http://www.scopus.com/inward/record.url?scp=0041785626&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041785626&partnerID=8YFLogxK

U2 - 10.1556/ABiol.54.2003.2.5

DO - 10.1556/ABiol.54.2003.2.5

M3 - Article

C2 - 14535622

AN - SCOPUS:0041785626

VL - 54

SP - 167

EP - 176

JO - Acta Biologica Hungarica

JF - Acta Biologica Hungarica

SN - 0236-5383

IS - 2

ER -