Restoration of energy level in the early phase of acute pediatric pancreatitis

Dóra Mosztbacher, Nelli Farkas, Margit Solymár, G. Pár, Judit Bajor, Ákos Szucs, József Czimmer, Katalin Márta, Alexandra Mikó, Zoltán Rumbus, Péter Varjú, P. Hegyi, Andrea Párniczky

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Acute pancreatitis (AP) is a serious inflammatory disease with rising incidence both in the adult and pediatric populations. It has been shown that mitochondrial injury and energy depletion are the earliest intracellular events in the early phase of AP. Moreover, it has been revealed that restoration of intracellular ATP level restores cellular functions and defends the cells from death. We have recently shown in a systematic review and meta-analysis that early enteral feeding is beneficial in adults; however, no reviews are available concerning the effect of early enteral feeding in pediatric AP. In this minireview, our aim was to systematically analyse the literature on the treatment of acute pediatric pancreatitis. The preferred reporting items for systematic review (PRISMA-P) were followed, and the question was drafted based on participants, intervention, comparison and outcomes: P: patients under the age of twenty-one suffering from acute pancreatitis; I: early enteral nutrition (per os and nasogastric- or nasojejunal tube started within 48 h); C: nil per os therapy; O: length of hospitalization, need for treatment at an intensive care unit, development of severe AP, lung injury (including lung oedema and pleural effusion), white blood cell count and pain score on admission. Altogether, 632 articles (PubMed: 131; EMBASE: 501) were found. After detailed screening of eligible papers, five of them met inclusion criteria. Only retrospective clinical trials were available. Due to insufficient information from the authors, it was only possible to address length of hospitalization as an outcome of the study. Our mini-meta-analysis showed that early enteral nutrition significantly (SD = 0.806, p = 0.034) decreases length of hospitalization compared with nil per os diet in acute pediatric pancreatitis. In this minireview, we clearly show that early enteral nutrition, started within 24-48 h, is beneficial in acute pediatric pancreatitis. Prospective studies and better presentation of research are crucially needed to achieve a higher level of evidence.

Original languageEnglish
Pages (from-to)957-963
Number of pages7
JournalWorld Journal of Gastroenterology
Volume23
Issue number6
DOIs
Publication statusPublished - 2017

Fingerprint

Pancreatitis
Pediatrics
Enteral Nutrition
Hospitalization
Meta-Analysis
Acute Lung Injury
Pleural Effusion
Leukocyte Count
Psychological Stress
PubMed
Intensive Care Units
Edema
Cell Death
Therapeutics
Adenosine Triphosphate
Outcome Assessment (Health Care)
Clinical Trials
Prospective Studies
Diet
Pain

Keywords

  • ATP restoration
  • Enteral nutrition
  • Length of hospitalization
  • Nil per os diet
  • Pediatric pancreatitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Mosztbacher, D., Farkas, N., Solymár, M., Pár, G., Bajor, J., Szucs, Á., ... Párniczky, A. (2017). Restoration of energy level in the early phase of acute pediatric pancreatitis. World Journal of Gastroenterology, 23(6), 957-963. https://doi.org/10.3748/wjg.v23.i6.957

Restoration of energy level in the early phase of acute pediatric pancreatitis. / Mosztbacher, Dóra; Farkas, Nelli; Solymár, Margit; Pár, G.; Bajor, Judit; Szucs, Ákos; Czimmer, József; Márta, Katalin; Mikó, Alexandra; Rumbus, Zoltán; Varjú, Péter; Hegyi, P.; Párniczky, Andrea.

In: World Journal of Gastroenterology, Vol. 23, No. 6, 2017, p. 957-963.

Research output: Contribution to journalReview article

Mosztbacher, D, Farkas, N, Solymár, M, Pár, G, Bajor, J, Szucs, Á, Czimmer, J, Márta, K, Mikó, A, Rumbus, Z, Varjú, P, Hegyi, P & Párniczky, A 2017, 'Restoration of energy level in the early phase of acute pediatric pancreatitis', World Journal of Gastroenterology, vol. 23, no. 6, pp. 957-963. https://doi.org/10.3748/wjg.v23.i6.957
Mosztbacher, Dóra ; Farkas, Nelli ; Solymár, Margit ; Pár, G. ; Bajor, Judit ; Szucs, Ákos ; Czimmer, József ; Márta, Katalin ; Mikó, Alexandra ; Rumbus, Zoltán ; Varjú, Péter ; Hegyi, P. ; Párniczky, Andrea. / Restoration of energy level in the early phase of acute pediatric pancreatitis. In: World Journal of Gastroenterology. 2017 ; Vol. 23, No. 6. pp. 957-963.
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