Restless legs syndrome, insomnia, and quality of life after renal transplantation

M. Molnár, M. Novák, L. Szeifert, C. Ambrus, Andras Keszei, Agnes Koczy, Anett Lindner, Szabolcs Barotfi, A. Szentkirályi, A. Remport, I. Mucsi

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Objective: Restless legs syndrome (RLS) is associated with insomnia and impaired quality of life (QoL) in patients on maintenance dialysis; however, no information has been published on the association of RLS and QoL in kidney-transplanted patients. In a cross-sectional study, we analyzed the complex relationship between RLS, insomnia, and health-related QoL in kidney-transplanted patients. Methods: In a cross-sectional survey at a single transplant center, 1067 patients were invited to participate. Complete data set was available from 785 kidney-transplanted patients. The RLS Questionnaire and the Athens Insomnia Scale were used to assess the prevalence of RLS and insomnia, respectively. QoL was measured using the Kidney Disease QoL-SF Questionnaire. Results: Patients with RLS were three times more likely to have insomnia than patients without RLS (29% vs. 9%, P=.001), and the presence of RLS was a significant and independent predictor of insomnia in multivariate analysis. The presence of RLS was independently associated with impaired health-related QoL along several QoL domains after statistical adjustment for clinical and sociodemographic covariables. Importantly, this association remained significant even after adjusting for insomnia for some QoL domains. Conclusion: RLS is associated with poor sleep, increased odds for insomnia, and impaired QoL in kidney-transplanted patients. Our results suggest that both sleep-related and sleep-independent factors may contribute to the association of RLS and QoL.

Original languageEnglish
Pages (from-to)591-597
Number of pages7
JournalJournal of Psychosomatic Research
Volume63
Issue number6
DOIs
Publication statusPublished - Dec 2007

Fingerprint

Restless Legs Syndrome
Sleep Initiation and Maintenance Disorders
Kidney Transplantation
Quality of Life
Kidney
Sleep
Cross-Sectional Studies
Kidney Diseases
Dialysis
Multivariate Analysis
Maintenance

Keywords

  • Chronic insomnia
  • Quality of life
  • Renal transplantation
  • Restless legs syndrome

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Restless legs syndrome, insomnia, and quality of life after renal transplantation. / Molnár, M.; Novák, M.; Szeifert, L.; Ambrus, C.; Keszei, Andras; Koczy, Agnes; Lindner, Anett; Barotfi, Szabolcs; Szentkirályi, A.; Remport, A.; Mucsi, I.

In: Journal of Psychosomatic Research, Vol. 63, No. 6, 12.2007, p. 591-597.

Research output: Contribution to journalArticle

@article{06680cbb40ba4569a168e1e012d341c5,
title = "Restless legs syndrome, insomnia, and quality of life after renal transplantation",
abstract = "Objective: Restless legs syndrome (RLS) is associated with insomnia and impaired quality of life (QoL) in patients on maintenance dialysis; however, no information has been published on the association of RLS and QoL in kidney-transplanted patients. In a cross-sectional study, we analyzed the complex relationship between RLS, insomnia, and health-related QoL in kidney-transplanted patients. Methods: In a cross-sectional survey at a single transplant center, 1067 patients were invited to participate. Complete data set was available from 785 kidney-transplanted patients. The RLS Questionnaire and the Athens Insomnia Scale were used to assess the prevalence of RLS and insomnia, respectively. QoL was measured using the Kidney Disease QoL-SF Questionnaire. Results: Patients with RLS were three times more likely to have insomnia than patients without RLS (29{\%} vs. 9{\%}, P=.001), and the presence of RLS was a significant and independent predictor of insomnia in multivariate analysis. The presence of RLS was independently associated with impaired health-related QoL along several QoL domains after statistical adjustment for clinical and sociodemographic covariables. Importantly, this association remained significant even after adjusting for insomnia for some QoL domains. Conclusion: RLS is associated with poor sleep, increased odds for insomnia, and impaired QoL in kidney-transplanted patients. Our results suggest that both sleep-related and sleep-independent factors may contribute to the association of RLS and QoL.",
keywords = "Chronic insomnia, Quality of life, Renal transplantation, Restless legs syndrome",
author = "M. Moln{\'a}r and M. Nov{\'a}k and L. Szeifert and C. Ambrus and Andras Keszei and Agnes Koczy and Anett Lindner and Szabolcs Barotfi and A. Szentkir{\'a}lyi and A. Remport and I. Mucsi",
year = "2007",
month = "12",
doi = "10.1016/j.jpsychores.2007.06.007",
language = "English",
volume = "63",
pages = "591--597",
journal = "Journal of Psychosomatic Research",
issn = "0022-3999",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Restless legs syndrome, insomnia, and quality of life after renal transplantation

AU - Molnár, M.

AU - Novák, M.

AU - Szeifert, L.

AU - Ambrus, C.

AU - Keszei, Andras

AU - Koczy, Agnes

AU - Lindner, Anett

AU - Barotfi, Szabolcs

AU - Szentkirályi, A.

AU - Remport, A.

AU - Mucsi, I.

PY - 2007/12

Y1 - 2007/12

N2 - Objective: Restless legs syndrome (RLS) is associated with insomnia and impaired quality of life (QoL) in patients on maintenance dialysis; however, no information has been published on the association of RLS and QoL in kidney-transplanted patients. In a cross-sectional study, we analyzed the complex relationship between RLS, insomnia, and health-related QoL in kidney-transplanted patients. Methods: In a cross-sectional survey at a single transplant center, 1067 patients were invited to participate. Complete data set was available from 785 kidney-transplanted patients. The RLS Questionnaire and the Athens Insomnia Scale were used to assess the prevalence of RLS and insomnia, respectively. QoL was measured using the Kidney Disease QoL-SF Questionnaire. Results: Patients with RLS were three times more likely to have insomnia than patients without RLS (29% vs. 9%, P=.001), and the presence of RLS was a significant and independent predictor of insomnia in multivariate analysis. The presence of RLS was independently associated with impaired health-related QoL along several QoL domains after statistical adjustment for clinical and sociodemographic covariables. Importantly, this association remained significant even after adjusting for insomnia for some QoL domains. Conclusion: RLS is associated with poor sleep, increased odds for insomnia, and impaired QoL in kidney-transplanted patients. Our results suggest that both sleep-related and sleep-independent factors may contribute to the association of RLS and QoL.

AB - Objective: Restless legs syndrome (RLS) is associated with insomnia and impaired quality of life (QoL) in patients on maintenance dialysis; however, no information has been published on the association of RLS and QoL in kidney-transplanted patients. In a cross-sectional study, we analyzed the complex relationship between RLS, insomnia, and health-related QoL in kidney-transplanted patients. Methods: In a cross-sectional survey at a single transplant center, 1067 patients were invited to participate. Complete data set was available from 785 kidney-transplanted patients. The RLS Questionnaire and the Athens Insomnia Scale were used to assess the prevalence of RLS and insomnia, respectively. QoL was measured using the Kidney Disease QoL-SF Questionnaire. Results: Patients with RLS were three times more likely to have insomnia than patients without RLS (29% vs. 9%, P=.001), and the presence of RLS was a significant and independent predictor of insomnia in multivariate analysis. The presence of RLS was independently associated with impaired health-related QoL along several QoL domains after statistical adjustment for clinical and sociodemographic covariables. Importantly, this association remained significant even after adjusting for insomnia for some QoL domains. Conclusion: RLS is associated with poor sleep, increased odds for insomnia, and impaired QoL in kidney-transplanted patients. Our results suggest that both sleep-related and sleep-independent factors may contribute to the association of RLS and QoL.

KW - Chronic insomnia

KW - Quality of life

KW - Renal transplantation

KW - Restless legs syndrome

UR - http://www.scopus.com/inward/record.url?scp=36549046921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36549046921&partnerID=8YFLogxK

U2 - 10.1016/j.jpsychores.2007.06.007

DO - 10.1016/j.jpsychores.2007.06.007

M3 - Article

C2 - 18061749

AN - SCOPUS:36549046921

VL - 63

SP - 591

EP - 597

JO - Journal of Psychosomatic Research

JF - Journal of Psychosomatic Research

SN - 0022-3999

IS - 6

ER -