Restless legs syndrome in patients after renal transplantation

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Abstract

Background: There is an almost complete lack of information on the epidemiology of sleep disorders in kidney-transplanted patients. In this report the authors assess the prevalence and clinical correlates of restless legs syndrome (RLS) in kidney-transplanted (Tx) patients. They also analyze the impact of declining renal function on this condition in the Tx population. Finally, the prevalence of RLS was compared between waitlisted dialysis patients (WL), and the Tx group. Methods: In a cross-sectional study enrolling 992 patients (816 Tx and 176 WL), the presence of RLS was assessed using the Restless Legs Syndrome Questionnaire. Clinical and sociodemographic data were collected from the patients' medical records. Results: In transplanted patients, the prevalence of RLS was 4.8%. RLS was associated strongly with declining renal function. In groups formed on the basis of estimated glomerular filtration rate (eGFR), the prevalence of RLS was 1.8%, 5.1%, 6.5%, and 23.5% in patients with eGFR greater than 60 mL/min/1.73 m2; eGFR 30 to 59 mL/min/1.73 m2; eGFR 15 to 29 mL/min/1.73 m2; and eGFR less than 15 mL/min/1.73 m2, respectively (P <0.001). There was also a significant association between RLS and lower serum hemoglobin, higher number of self-reported comorbid conditions, and higher prevalence of iron deficiency. RLS was significantly less frequent in patients taking steroids than in patients not taking this medication (4% versus 9%, P <0.05). In multivariate analysis, not taking steroids, eGFR, self-reported comorbidity, and iron deficiency were significant and independent predictors of RLS. Dialysis treatment was associated with increased odds for RLS (odds ratio 2.2; 95% confidence interval 1.11 to 4.35; P <0.05) even after adjusting for serum hemoglobin and comorbidity. Conclusion: The prevalence of RLS is significantly lower in Tx patients than in patients on maintenance dialysis. Declining renal function is associated with increasing prevalence of the condition.

Original languageEnglish
Pages (from-to)388-396
Number of pages9
JournalAmerican Journal of Kidney Diseases
Volume45
Issue number2
DOIs
Publication statusPublished - Feb 2005

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Restless Legs Syndrome
Kidney Transplantation
Glomerular Filtration Rate
Kidney
Dialysis
Comorbidity
Hemoglobins
Iron
Steroids
Serum
Medical Records
Epidemiology
Multivariate Analysis

Keywords

  • Chronic kidney disease
  • Dialysis
  • End-stage renal disease (ESRD)
  • Kidney transplantation
  • Restless legs syndrome

ASJC Scopus subject areas

  • Nephrology

Cite this

@article{cba25b3836304d93988d966bab56e498,
title = "Restless legs syndrome in patients after renal transplantation",
abstract = "Background: There is an almost complete lack of information on the epidemiology of sleep disorders in kidney-transplanted patients. In this report the authors assess the prevalence and clinical correlates of restless legs syndrome (RLS) in kidney-transplanted (Tx) patients. They also analyze the impact of declining renal function on this condition in the Tx population. Finally, the prevalence of RLS was compared between waitlisted dialysis patients (WL), and the Tx group. Methods: In a cross-sectional study enrolling 992 patients (816 Tx and 176 WL), the presence of RLS was assessed using the Restless Legs Syndrome Questionnaire. Clinical and sociodemographic data were collected from the patients' medical records. Results: In transplanted patients, the prevalence of RLS was 4.8{\%}. RLS was associated strongly with declining renal function. In groups formed on the basis of estimated glomerular filtration rate (eGFR), the prevalence of RLS was 1.8{\%}, 5.1{\%}, 6.5{\%}, and 23.5{\%} in patients with eGFR greater than 60 mL/min/1.73 m2; eGFR 30 to 59 mL/min/1.73 m2; eGFR 15 to 29 mL/min/1.73 m2; and eGFR less than 15 mL/min/1.73 m2, respectively (P <0.001). There was also a significant association between RLS and lower serum hemoglobin, higher number of self-reported comorbid conditions, and higher prevalence of iron deficiency. RLS was significantly less frequent in patients taking steroids than in patients not taking this medication (4{\%} versus 9{\%}, P <0.05). In multivariate analysis, not taking steroids, eGFR, self-reported comorbidity, and iron deficiency were significant and independent predictors of RLS. Dialysis treatment was associated with increased odds for RLS (odds ratio 2.2; 95{\%} confidence interval 1.11 to 4.35; P <0.05) even after adjusting for serum hemoglobin and comorbidity. Conclusion: The prevalence of RLS is significantly lower in Tx patients than in patients on maintenance dialysis. Declining renal function is associated with increasing prevalence of the condition.",
keywords = "Chronic kidney disease, Dialysis, End-stage renal disease (ESRD), Kidney transplantation, Restless legs syndrome",
author = "Molnar, {Miklos Zsolt} and Marta Novak and Csaba Ambrus and Lilla Szeifert and Agnes Kovacs and Judit Pap and Adam Remport and Istvan Mucsi",
year = "2005",
month = "2",
doi = "10.1053/j.ajkd.2004.10.007",
language = "English",
volume = "45",
pages = "388--396",
journal = "American Journal of Kidney Diseases",
issn = "0272-6386",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Restless legs syndrome in patients after renal transplantation

AU - Molnar, Miklos Zsolt

AU - Novak, Marta

AU - Ambrus, Csaba

AU - Szeifert, Lilla

AU - Kovacs, Agnes

AU - Pap, Judit

AU - Remport, Adam

AU - Mucsi, Istvan

PY - 2005/2

Y1 - 2005/2

N2 - Background: There is an almost complete lack of information on the epidemiology of sleep disorders in kidney-transplanted patients. In this report the authors assess the prevalence and clinical correlates of restless legs syndrome (RLS) in kidney-transplanted (Tx) patients. They also analyze the impact of declining renal function on this condition in the Tx population. Finally, the prevalence of RLS was compared between waitlisted dialysis patients (WL), and the Tx group. Methods: In a cross-sectional study enrolling 992 patients (816 Tx and 176 WL), the presence of RLS was assessed using the Restless Legs Syndrome Questionnaire. Clinical and sociodemographic data were collected from the patients' medical records. Results: In transplanted patients, the prevalence of RLS was 4.8%. RLS was associated strongly with declining renal function. In groups formed on the basis of estimated glomerular filtration rate (eGFR), the prevalence of RLS was 1.8%, 5.1%, 6.5%, and 23.5% in patients with eGFR greater than 60 mL/min/1.73 m2; eGFR 30 to 59 mL/min/1.73 m2; eGFR 15 to 29 mL/min/1.73 m2; and eGFR less than 15 mL/min/1.73 m2, respectively (P <0.001). There was also a significant association between RLS and lower serum hemoglobin, higher number of self-reported comorbid conditions, and higher prevalence of iron deficiency. RLS was significantly less frequent in patients taking steroids than in patients not taking this medication (4% versus 9%, P <0.05). In multivariate analysis, not taking steroids, eGFR, self-reported comorbidity, and iron deficiency were significant and independent predictors of RLS. Dialysis treatment was associated with increased odds for RLS (odds ratio 2.2; 95% confidence interval 1.11 to 4.35; P <0.05) even after adjusting for serum hemoglobin and comorbidity. Conclusion: The prevalence of RLS is significantly lower in Tx patients than in patients on maintenance dialysis. Declining renal function is associated with increasing prevalence of the condition.

AB - Background: There is an almost complete lack of information on the epidemiology of sleep disorders in kidney-transplanted patients. In this report the authors assess the prevalence and clinical correlates of restless legs syndrome (RLS) in kidney-transplanted (Tx) patients. They also analyze the impact of declining renal function on this condition in the Tx population. Finally, the prevalence of RLS was compared between waitlisted dialysis patients (WL), and the Tx group. Methods: In a cross-sectional study enrolling 992 patients (816 Tx and 176 WL), the presence of RLS was assessed using the Restless Legs Syndrome Questionnaire. Clinical and sociodemographic data were collected from the patients' medical records. Results: In transplanted patients, the prevalence of RLS was 4.8%. RLS was associated strongly with declining renal function. In groups formed on the basis of estimated glomerular filtration rate (eGFR), the prevalence of RLS was 1.8%, 5.1%, 6.5%, and 23.5% in patients with eGFR greater than 60 mL/min/1.73 m2; eGFR 30 to 59 mL/min/1.73 m2; eGFR 15 to 29 mL/min/1.73 m2; and eGFR less than 15 mL/min/1.73 m2, respectively (P <0.001). There was also a significant association between RLS and lower serum hemoglobin, higher number of self-reported comorbid conditions, and higher prevalence of iron deficiency. RLS was significantly less frequent in patients taking steroids than in patients not taking this medication (4% versus 9%, P <0.05). In multivariate analysis, not taking steroids, eGFR, self-reported comorbidity, and iron deficiency were significant and independent predictors of RLS. Dialysis treatment was associated with increased odds for RLS (odds ratio 2.2; 95% confidence interval 1.11 to 4.35; P <0.05) even after adjusting for serum hemoglobin and comorbidity. Conclusion: The prevalence of RLS is significantly lower in Tx patients than in patients on maintenance dialysis. Declining renal function is associated with increasing prevalence of the condition.

KW - Chronic kidney disease

KW - Dialysis

KW - End-stage renal disease (ESRD)

KW - Kidney transplantation

KW - Restless legs syndrome

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U2 - 10.1053/j.ajkd.2004.10.007

DO - 10.1053/j.ajkd.2004.10.007

M3 - Article

C2 - 15685518

AN - SCOPUS:15944382707

VL - 45

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EP - 396

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

SN - 0272-6386

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